The role of nicotinamide in cancer chemoprevention and therapy

IP Nikas, SA Paschou, HS Ryu - Biomolecules, 2020 - mdpi.com
Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of
nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism …

SIRT1 and estrogen signaling cooperation for breast cancer onset and progression

S Liarte, JL Alonso-Romero, FJ Nicolás - Frontiers in endocrinology, 2018 - frontiersin.org
Breast cancer remains a significant female mortality cause. It constitutes a multifactorial
disease for which research on environmental factors offers little help in predicting onset or …

Suppression of epithelial-mesenchymal transition and SIRT1/AKT signaling pathway in breast cancer by montelukast

NE El-Ashmawy, EG Khedr, NF Khedr… - International …, 2023 - Elsevier
Background Breast cancer is usually associated with metastatic features, poor prognosis,
and high mortality. The epithelial-mesenchymal transition (EMT) process has been …

SRC promotes tamoxifen resistance in breast cancer via up-regulating SIRT1

J Zhou, M Xu, K Le, J Ming, H Guo, S Ruan… - OncoTargets and …, 2020 - Taylor & Francis
Background Endocrine therapy plays a key role in estrogen receptor-positive breast cancer
patients; but, tamoxifen resistance could be a real difficulty for these patients. Several …

[HTML][HTML] Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1)

MH Lin, A Islam, YH Liu, CW Weng… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Bladder cancer is one of the most frequent cancers among males, and a poor survival rate
reflects problems with aggressiveness and chemo-resistance. Accumulating evidence …

Survival and clinicopathological significance of SIRT1 expression in cancers: a meta-analysis

M Sun, M Du, W Zhang, S Xiong, X Gong… - Frontiers in …, 2019 - frontiersin.org
Background: Silent information regulator 2 homolog 1 (SIRT1) is an evolutionarily conserved
enzymes with nicotinamide adenine dinucleotide (NAD)+-dependent deacetylase activity …

Post-Translational Modifications by Lipid Metabolites during the DNA Damage Response and Their Role in Cancer

G Zhu, X Zheng, Z Wang, X Xu - Biomolecules, 2022 - mdpi.com
Genomic DNA damage occurs as an inevitable consequence of exposure to harmful
exogenous and endogenous agents. Therefore, the effective sensing and repair of DNA …

[HTML][HTML] 10-姜酚通过Src/STAT3 信号通路抑制肝癌HepG2 细胞增殖

陈建新, 吴依芬, 李树基, 吴洪渊… - Journal of Southern …, 2018 - ncbi.nlm.nih.gov
10-姜酚通过Src/STAT3信号通路抑制肝癌HepG2细胞增殖- PMC Back to Top Skip to main
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …

[PDF][PDF] Discover Oncology

ZF Zhang, F Liu, HR Zhang, B Liu, SQ Zheng, WQ Ye… - Discover, 2023 - d-nb.info
Background Breast cancer (BC) is the most common malignancy among women in the
world. Alternative splicing (AS) is an important mechanism for regulating gene expression …

Study of hsa_circRNA_000121 and hsa_circRNA_004183 in papillary thyroid microcarcinoma

C Bai, W Yang, R Ouyang, Z Li, L Zhang - Open Life Sciences, 2022 - degruyter.com
We detected the expressions of hsa_circRNA_000121 and hsa_circRNA_ 004183 in
papillary thyroid microcarcinoma (PTMC) and explored their relationship with the …