Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation in the
absence of excessive alcohol consumption and is strongly associated with obesity, type 2 …

The incidence of nonalcoholic fatty liver disease (NAFLD) is on the rise, mirroring a global
surge in diabetes and metabolic syndrome, as its major leading causes. NAFLD represents …

Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that
enable the exchange of calcium and phospholipids. Disturbed contacts between ER and …

Coronary microvascular dysfunction (CMD) is associated with cardiac dysfunction and
predictive of cardiac mortality in obesity, especially in females. Clinical data further support …

Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered
considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity …

Introduction Endoplasmic reticulum (ER) stress occurs with aberrant lipid accumulation and
resultant adverse effects and widely exists in nonalcoholic fatty liver disease (NAFLD). It …

Hemophilia A gene therapy targets hepatocytes to express B domain deleted (BDD) clotting
factor VIII (FVIII) to permit viral encapsidation. Since BDD is prone to misfolding in the …

Objective: To investigate how Hydroxysafflor yellow A (HSYA) effects acute liver injury (ALI)
and what transcriptional regulatory mechanisms it may employ. Methods: Rats were …

CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD)
protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor …