Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Simple Summary The progressive nature of type 2 diabetes mellitus (T2DM) leads to micro-
and macro-vascular complications, including renal and cardiovascular disease. These …

Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of
fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several …

Unilateral ureteral obstruction (UUO) is an experimental rodent model that mimics renal
fibrosis associated with obstructive nephropathy in an accelerated manner. After UUO, the …

Ruxolitinib is a selective inhibitor of Jak1/2. Downstream signaling pathways of Jak, such as
Stat3 and Akt/mTOR, are overactivated and contribute to renal interstitial fibrosis. Therefore …

Autophagy is a dynamic process by which intracellular damaged macromolecules and
organelles are degraded and recycled for the synthesis of new cellular components. Basal …

Fibrosis occurs in most human organs including the liver, lung, heart and kidney, and is
crucial for the progression of most chronic diseases. As an indispensable catabolic process …

Renal fibrosis is the final common pathway of all chronic kidney diseases progressing to end-
stage renal diseases. Autophagy, a highly conserved lysosomal degradation pathway, plays …

Tissue repair and fibrosis, an abnormal form of repair, occur in most human organs in
response to injury or inflammation. Fibroblasts play a major role in the normal repair process …

Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been
used as an herbal complementary and alternative medicine with various biological activities …