Adverse reactions in normal tissue after radiotherapy (RT) limit the dose that can be given to
tumour cells. Since 80% of individual variation in clinical response is estimated to be caused …

In 1936, Holthusen theorized the probability of achieving tumor control and of developing
normal tissue complications after radiotherapy as a function of radiation dose. This concept …

Background Monocentric cohorts suggested that radiation-induced CD8 T-lymphocyte
apoptosis (RILA) can predict late toxicity after curative intent radiotherapy (RT). We …

Abstract Purpose: The workshop on 'Individual Radiosensitivity and Radiosusceptibility'
organized by MELODI and CONCERT on Malta in 2018, evaluated the current state of …

Whilst the near instantaneous physical interaction of radiation energy with living cells leaves
little opportunity for inter-individual variation in the initial yield of DNA damage, all the …

Simple Summary Over 50% of patients with cancer will receive radiotherapy treatment. Five
to ten percent of patients who received radiotherapy will develop side effects. Identifying …

Growing genetic and molecular biological evidence suggests that the disruption of balance
between Secreted Frizzled-Related Protein-1 (SFRP1) and β-catenin plays an important role …

Prostate cancer (PCa) is one of the most prevalent malignancies in males worldwide.
Increasing research attention has focused on the PCa microenvironment, which plays a …

Abstract Background Shifts in CD8+ T-cell subsets that are hallmarks of immunosenescence
are observed in ageing and in conditions of chronic immune stimulation. Presently, there is …

Background We present here final clinical results of the COHORT trial and both translational
sub-studies aiming at identifying patients at risk of radiation-induced subcutaneous fibrosis …