Biology, vulnerabilities and clinical applications of circulating tumour cells
In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …
Multifunctional biomolecule nanostructures for cancer therapy
J Wang, Y Li, G Nie - Nature Reviews Materials, 2021 - nature.com
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …
biological activities, which can be explored for cancer nanomedicine. The supramolecular …
Spatially resolved clonal copy number alterations in benign and malignant tissue
A Erickson, M He, E Berglund, M Marklund… - Nature, 2022 - nature.com
Defining the transition from benign to malignant tissue is fundamental to improving early
diagnosis of cancer. Here we use a systematic approach to study spatial genome integrity in …
diagnosis of cancer. Here we use a systematic approach to study spatial genome integrity in …
MRI-targeted or standard biopsy for prostate-cancer diagnosis
V Kasivisvanathan, AS Rannikko… - … England Journal of …, 2018 - Mass Medical Soc
Background Multiparametric magnetic resonance imaging (MRI), with or without targeted
biopsy, is an alternative to standard transrectal ultrasonography–guided biopsy for prostate …
biopsy, is an alternative to standard transrectal ultrasonography–guided biopsy for prostate …
Molecular landmarks of tumor hypoxia across cancer types
Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …
Tumour heterogeneity and resistance to cancer therapies
I Dagogo-Jack, AT Shaw - Nature reviews Clinical oncology, 2018 - nature.com
Cancer is a dynamic disease. During the course of disease, cancers generally become more
heterogeneous. As a result of this heterogeneity, the bulk tumour might include a diverse …
heterogeneous. As a result of this heterogeneity, the bulk tumour might include a diverse …
Clinical implications of intratumor heterogeneity: challenges and opportunities
S Ramón y Cajal, M Sesé, C Capdevila… - Journal of Molecular …, 2020 - Springer
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …
Surveillance or metastasis-directed therapy for oligometastatic prostate cancer recurrence: a prospective, randomized, multicenter phase II trial
P Ost, D Reynders, K Decaestecker… - Journal of Clinical …, 2018 - ascopubs.org
Purpose Retrospective studies suggest that metastasis-directed therapy (MDT) for
oligorecurrent prostate cancer (PCa) improves progression-free survival. We aimed to …
oligorecurrent prostate cancer (PCa) improves progression-free survival. We aimed to …
Genomic and phenotypic heterogeneity in prostate cancer
From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …
heterogeneous disease. Primary prostate cancers are often multifocal, having …
Genetics and biology of prostate cancer
Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …