Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical,
organizational and signaling roles. Because many cytoskeletal proteins are sensitive to …

The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and
regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point …

Nitric oxide (NO) is a powerful mediator with biological activities such as vasodilation and
prevention of vascular smooth muscle cell proliferation as well as functional regulation of …

Titin is a giant scaffold protein with multiple functions in striated muscle physiology. Due to
the elastic I-band domains and the filament-like integration in the half-sarcomere titin is an …

Skeletal muscle, a highly complex muscle type in the eukaryotic system, is characterized by
different muscle subtypes and functions associated with specific myosin isoforms. As a …

Reversible post-translational modifications of various cardiac proteins regulate the
mechanical properties of the cardiomyocytes and thus modulate the contractile performance …

Actin and its ability to polymerize into dynamic filaments is critical for the form and function of
cells throughout the body. While multiple proteins have been characterized as affecting actin …

Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

Aims: Cysteine (Cys) is a major target for redox post-translational modifications (PTMs) that
occur in response to changes in the cellular redox environment. We describe multiplexed …