Structural dynamics of P-type ATPase ion pumps

M Dyla, S Basse Hansen, P Nissen… - Biochemical Society …, 2019 - portlandpress.com
P-type ATPases transport ions across biological membranes against concentration
gradients and are essential for all cells. They use the energy from ATP hydrolysis to propel …

Specific interactions of peripheral membrane proteins with lipids: what can molecular simulations show us?

AH Larsen, LH John, MSP Sansom… - Bioscience …, 2022 - portlandpress.com
Peripheral membrane proteins (PMPs) can reversibly and specifically bind to biological
membranes to carry out functions such as cell signalling, enzymatic activity, or membrane …

Combining molecular dynamics simulations with small-angle X-ray and neutron scattering data to study multi-domain proteins in solution

AH Larsen, Y Wang, S Bottaro, S Grudinin… - PLoS computational …, 2020 - journals.plos.org
Many proteins contain multiple folded domains separated by flexible linkers, and the ability
to describe the structure and conformational heterogeneity of such flexible systems pushes …

Neutron scattering in the biological sciences: progress and prospects

R Ashkar, H Bilheux, H Bordallo, R Briber… - … Section D: Structural …, 2018 - journals.iucr.org
The scattering of neutrons can be used to provide information on the structure and dynamics
of biological systems on multiple length and time scales. Pursuant to a National Science …

Human myelin proteolipid protein structure and lipid bilayer stacking

S Ruskamo, A Raasakka, JS Pedersen… - Cellular and Molecular …, 2022 - Springer
The myelin sheath is an essential, multilayered membrane structure that insulates axons,
enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein …

[HTML][HTML] Travel light: Essential packing for membrane proteins with an active lifestyle

NT Johansen, FG Tidemand, MC Pedersen, L Arleth - Biochimie, 2023 - Elsevier
We review the considerable progress during the recent decade in the endeavours of
designing, optimising, and utilising carrier particle systems for structural and functional …

Tracking Ca2+ ATPase intermediates in real-time by X-ray solution scattering

H Ravishankar, MN Pedersen, A Sitsel, C Li, A Duelli… - Biophysical …, 2020 - cell.com
The Ca 2+-transporting sarcoplasmic reticulum ATPase (SERCA) is a membrane protein
transporter involved in calcium signalling by active Ca 2+ reuptake to internal stores …

Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation

NT Johansen, M Bonaccorsi, T Bengtsen, AH Larsen… - Elife, 2022 - elifesciences.org
The CorA family of proteins regulates the homeostasis of divalent metal ions in many
bacteria, archaea, and eukaryotic mitochondria, making it an important target in the …

Introducing SEC–SANS for studies of complex self-organized biological systems

NT Johansen, MC Pedersen, L Porcar… - … Section D: Structural …, 2018 - journals.iucr.org
Small-angle neutron scattering (SANS) is maturing as a method for studying complex
biological structures. Owing to the intrinsic ability of the technique to discern between 1H …

Assessment of structure factors for analysis of small-angle scattering data from desired or undesired aggregates

AH Larsen, JS Pedersen, L Arleth - Journal of applied …, 2020 - journals.iucr.org
Aggregation processes are central features of many systems ranging from colloids and
polymers to inorganic nanoparticles and biological systems. Some aggregated structures …