AICAr, a widely used AMPK activator with important AMPK-independent effects: a systematic review
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most
commonly used pharmacological modulators of AMPK activity. The majority of early studies …
commonly used pharmacological modulators of AMPK activity. The majority of early studies …
Cytarabine-induced differentiation of AML cells depends on Chk1 activation and shares the mechanism with inhibitors of DHODH and pyrimidine synthesis
Acute myeloid leukemia (AML) is characterized by arrested differentiation making
differentiation therapy a promising treatment strategy. Recent success of inhibitors of …
differentiation therapy a promising treatment strategy. Recent success of inhibitors of …
Bone marrow stromal cells reduce low-dose cytarabine-induced differentiation of acute myeloid leukemia
Low-dose cytarabine (LDAC) is a standard therapy for elderly acute myeloid leukemia (AML)
patients unfit for intensive chemotherapy. While high doses of cytarabine induce cytotoxicity …
patients unfit for intensive chemotherapy. While high doses of cytarabine induce cytotoxicity …
[HTML][HTML] A combined chemical, computational, and in vitro approach identifies SBL-105 as novel DHODH inhibitor in acute myeloid leukemia cells
Inhibition of the dihydroorotate dehydrogenase (DHODH) has been successful at the
preclinical level in controlling myeloid leukemia. However, poor clinical trials warrant the …
preclinical level in controlling myeloid leukemia. However, poor clinical trials warrant the …
All-trans retinoic acid induces differentiation in primary acute myeloid leukemia blasts carrying an inversion of chromosome 16
All-trans retinoic acid (ATRA)-based therapy for acute promyelocytic leukemia (APL), a
subtype of acute myeloid leukemia (AML), is the most successful example of differentiation …
subtype of acute myeloid leukemia (AML), is the most successful example of differentiation …
Bone Marrow Stromal Cells Enhance Differentiation of Acute Myeloid Leukemia Induced by Pyrimidine Synthesis Inhibitors
Acute myeloid leukemia (AML) is a heterogeneous group of hematologic malignancies
characterized by differentiation arrest, high relapse rates, and poor survival. The bone …
characterized by differentiation arrest, high relapse rates, and poor survival. The bone …
[PDF][PDF] Barbara Tomic1, 2, Tomislav Smoljo1, 2, Hrvoje Lalic1, 2, Vilma Dembitz1, 2, Josip Batinic3
D Batinic, A Bedalov, D Visnjic - Scientific Reports, 2022 - bib.irb.hr
Acute myeloid leukemia (AML) is characterized by arrested differentiation making
differentiation therapy a promising treatment strategy. Recent success of inhibitors of …
differentiation therapy a promising treatment strategy. Recent success of inhibitors of …
Mehanizam diferencijacije stanica akutne mijeloične leukemije potaknute citarabinom
T Smoljo - 2024 - repozitorij.unizg.hr
Sažetak Citarabin u malim koncentracijama potiče diferencijaciju stanica akutne mijeloične
leukemije (AML), ali mehanizam nije u potpunosti objašnjen. Naša prethodna istraživanja …
leukemije (AML), ali mehanizam nije u potpunosti objašnjen. Naša prethodna istraživanja …
Signalni mehanizmi i metaboličke promjene tijekom diferencijacije i proliferacije leukemijskih stanica
B Tomić - 2022 - repozitorij.unizg.hr
aminoimidazol-4-karboksamid ribonukleozid (AIKAr) prekursor je u biosintezi purina i
poznati aktivator kinaze ovisne o AMP-u (AMPK). Naše je prethodno istraživanje pokazalo …
poznati aktivator kinaze ovisne o AMP-u (AMPK). Naše je prethodno istraživanje pokazalo …