Malaria is a devastating infectious disease that is caused by blood-borne apicomplexan
parasites of the genus Plasmodium. These pathogens have a complex lifecycle, which …

Microbial drug persistence is a widespread phenomenon in which a subpopulation of
microorganisms is able to survive antimicrobial treatment without acquiring resistance …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

INTRODUCTION Plasmodium parasites, the causative agent of malaria, are single-celled
organisms with distinct morphological developmental stages each specialized to inhabit …

The life cycles of many parasites involve transitions between disparate host species,
requiring these parasites to go through multiple developmental stages adapted to each of …

Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each
replication cycle, some parasites differentiate into gametocytes, the only forms able to infect …

Single-cell RNA-sequencing is revolutionising our understanding of seemingly
homogeneous cell populations but has not yet been widely applied to single-celled …

Clonally variant expression of surface antigens allows the malaria parasite Plasmodium
falciparum to evade immune recognition during blood stage infection and secure malaria …

Due to their remarkable parasitocidal activity, artemisinins represent the key components of
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …

The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic
persistence in human red blood cells, continuously evading host immunity using …