Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …

Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–
control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole …

Alzheimer's disease (AD) is characterized by plaques containing amyloid-β (Aβ) and
neurofibrillary tangles composed of aggregated, hyperphosphorylated tau. Beyond tau and …

We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …

Accumulation of hyperphosphorylated tau directly correlates with cognitive decline in
Alzheimer's disease and other primary tauopathies. One therapeutic strategy may be to …