From actin waves to mechanism and back: how theory aids biological understanding

C Beta, L Edelstein-Keshet, N Gov, A Yochelis - Elife, 2023 - elifesciences.org
Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

Clathrin-independent endocytosis: an increasing degree of complexity

K Sandvig, S Kavaliauskiene, T Skotland - Histochemistry and cell biology, 2018 - Springer
This article aims at providing an update on the complexity of clathrin-independent
endocytosis. It is now almost 30 years since we first wrote a review about its existence; at …

Macropinocytosis: mechanisms and regulation

G Salloum, AR Bresnick, JM Backer - Biochemical Journal, 2023 - portlandpress.com
Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Porous silicon nanoneedles modulate endocytosis to deliver biological payloads

S Gopal, C Chiappini, J Penders… - Advanced …, 2019 - Wiley Online Library
Owing to their ability to efficiently deliver biological cargo and sense the intracellular milieu,
vertical arrays of high aspect ratio nanostructures, known as nanoneedles, are being …

Macropinocytosis, mTORC1 and cellular growth control

S Yoshida, R Pacitto, K Inoki, J Swanson - Cellular and molecular life …, 2018 - Springer
The growth and proliferation of metazoan cells are driven by cellular nutrient status and by
extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical …

HCMV induces macropinocytosis for host cell entry in fibroblasts

S Hetzenecker, A Helenius, MA Krzyzaniak - Traffic, 2016 - Wiley Online Library
Human cytomegalovirus (HCMV) is an important and widespread pathogen in the human
population. While infection by this β‐herpesvirus in endothelial, epithelial and dendritic cells …

Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking

P Croisé, C Estay-Ahumada, S Gasman, S Ory - Small GTPases, 2014 - Taylor & Francis
Rho GTPases are well known regulators of the actin cytoskeleton that act by binding and
activating actin nucleators. They are therefore involved in many actin-based processes …

Arf GAPs as regulators of the actin cytoskeleton—an update

CE Tanna, LB Goss, CG Ludwig, PW Chen - International journal of …, 2019 - mdpi.com
Arf GTPase-activating proteins (Arf GAPs) control the activity of ADP-ribosylation factors
(Arfs) by inducing GTP hydrolysis and participate in a diverse array of cellular functions both …

Lamellipodia-like actin networks in cells lacking WAVE regulatory complex

F Kage, H Döring, M Mietkowska… - Journal of Cell …, 2022 - journals.biologists.com
Cell migration frequently involves the formation of lamellipodia induced by Rac GTPases
activating WAVE regulatory complex (WRC) to drive Arp2/3 complex-dependent actin …

Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles

E Bernitt, HG Döbereiner, NS Gov… - Nature Communications, 2017 - nature.com
During macropinocytosis, cells remodel their morphologies for the uptake of extracellular
matter. This endocytotic mechanism relies on the collapse and closure of precursory …