From actin waves to mechanism and back: how theory aids biological understanding
Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
Clathrin-independent endocytosis: an increasing degree of complexity
K Sandvig, S Kavaliauskiene, T Skotland - Histochemistry and cell biology, 2018 - Springer
This article aims at providing an update on the complexity of clathrin-independent
endocytosis. It is now almost 30 years since we first wrote a review about its existence; at …
endocytosis. It is now almost 30 years since we first wrote a review about its existence; at …
Macropinocytosis: mechanisms and regulation
G Salloum, AR Bresnick, JM Backer - Biochemical Journal, 2023 - portlandpress.com
Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …
Porous silicon nanoneedles modulate endocytosis to deliver biological payloads
S Gopal, C Chiappini, J Penders… - Advanced …, 2019 - Wiley Online Library
Owing to their ability to efficiently deliver biological cargo and sense the intracellular milieu,
vertical arrays of high aspect ratio nanostructures, known as nanoneedles, are being …
vertical arrays of high aspect ratio nanostructures, known as nanoneedles, are being …
Macropinocytosis, mTORC1 and cellular growth control
The growth and proliferation of metazoan cells are driven by cellular nutrient status and by
extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical …
extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical …
HCMV induces macropinocytosis for host cell entry in fibroblasts
S Hetzenecker, A Helenius, MA Krzyzaniak - Traffic, 2016 - Wiley Online Library
Human cytomegalovirus (HCMV) is an important and widespread pathogen in the human
population. While infection by this β‐herpesvirus in endothelial, epithelial and dendritic cells …
population. While infection by this β‐herpesvirus in endothelial, epithelial and dendritic cells …
Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking
P Croisé, C Estay-Ahumada, S Gasman, S Ory - Small GTPases, 2014 - Taylor & Francis
Rho GTPases are well known regulators of the actin cytoskeleton that act by binding and
activating actin nucleators. They are therefore involved in many actin-based processes …
activating actin nucleators. They are therefore involved in many actin-based processes …
Arf GAPs as regulators of the actin cytoskeleton—an update
CE Tanna, LB Goss, CG Ludwig, PW Chen - International journal of …, 2019 - mdpi.com
Arf GTPase-activating proteins (Arf GAPs) control the activity of ADP-ribosylation factors
(Arfs) by inducing GTP hydrolysis and participate in a diverse array of cellular functions both …
(Arfs) by inducing GTP hydrolysis and participate in a diverse array of cellular functions both …
Lamellipodia-like actin networks in cells lacking WAVE regulatory complex
F Kage, H Döring, M Mietkowska… - Journal of Cell …, 2022 - journals.biologists.com
Cell migration frequently involves the formation of lamellipodia induced by Rac GTPases
activating WAVE regulatory complex (WRC) to drive Arp2/3 complex-dependent actin …
activating WAVE regulatory complex (WRC) to drive Arp2/3 complex-dependent actin …
Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
E Bernitt, HG Döbereiner, NS Gov… - Nature Communications, 2017 - nature.com
During macropinocytosis, cells remodel their morphologies for the uptake of extracellular
matter. This endocytotic mechanism relies on the collapse and closure of precursory …
matter. This endocytotic mechanism relies on the collapse and closure of precursory …