Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

Amyloidoses are a group of diseases associated with deposits of amyloid fibrils in different
tissues. So far, 36 different types of amyloidosis are known, each due to the misfolding and …

This review was written in memory of our late friend, Dr. Hiroyuki Sorimachi, who, following
the steps of his mentor Koichi Suzuki, a pioneer in calpain research, has made tremendous …

In Parkinson's disease, aggregates of α-synuclein within Lewy bodies and Lewy neurites
represent neuropathological hallmarks. However, the cellular and molecular mechanisms …

Calpain is defined as a member of the superfamily of cysteine proteases possessing the
CysPC motif within the gene. Calpain-1 and-2, which are categorized as conventional …

After adult mammalian central nervous system injury, axon regeneration is extremely limited
or absent, resulting in persistent neurological deficits. Axon regeneration failure is due in …

Background A number of membrane-anchored proteins are known to be released from cell
surface via ectodomain shedding. The cleavage and release of membrane proteins has …

The intercalated disk is a cardiac specific structure composed of three main protein
complexes—adherens junctions, desmosomes, and gap junctions—that work in concert to …

Abstract The DEFECTIVE KERNEL1 (DEK1) calpain is a conserved 240-kD key regulator of
three-dimensional body patterning in land plants acting via mitotic cell plane positioning …

Abstract Calpain-1 and calpain-2 are highly structurally similar isoforms of calpain. The
calpains, a family of intracellular cysteine proteases, cleave their substrates at specific sites …