Caffeoylquinic acids: Chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

A Alcázar Magaña, N Kamimura… - The plant …, 2021 - Wiley Online Library
Caffeoylquinic acids (CQAs) are specialized plant metabolites we encounter in our daily life.
Humans consume CQAs in mg‐to‐gram quantities through dietary consumption of plant …

Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects

H Xue, M Wei, L Ji - Phytomedicine, 2023 - Elsevier
Background Liver diseases have a negative impact on global health and are a leading
cause of death worldwide. Chlorogenic acids (CGAs), a family of esters formed between …

[HTML][HTML] A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

X Luo, X Weng, X Bao, X Bai, Y Lv, S Zhang, Y Chen… - Redox Biology, 2022 - Elsevier
Natural antioxidants represented by quercetin have been documented to be effective
against atherosclerosis. However, the related mechanisms remain largely unclear. In this …

[HTML][HTML] Advances in understanding the role of NRF2 in liver pathophysiology and its relationship with hepatic-specific Cyclooxygenase-2 expression

M Fuertes-Agudo, M Luque-Tévar, C Cucarella… - Antioxidants, 2023 - mdpi.com
Oxidative stress and inflammation play an important role in the pathophysiological changes
of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor …

A review of the protective effects of chlorogenic acid against different chemicals

R Rashidi, R Rezaee, A Shakeri… - Journal of Food …, 2022 - Wiley Online Library
Chlorogenic acid (CGA) is a naturally occurring non‐flavonoid polyphenol found in green
coffee beans, teas, certain fruits, and vegetables, that exerts antiviral, antitumor …

[HTML][HTML] The potential effects of quercetin-loaded nanoliposomes on amoxicillin/clavulanate-induced hepatic damage: targeting the Sirt1/Nrf2/Nf-κB signaling pathway …

MM Abd El-Emam, M Mostafa, AA Farag, HS Youssef… - Antioxidants, 2023 - mdpi.com
Amoxicillin/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial
infections, has been associated with drug-induced liver damage. Quercetin (QR), a naturally …

Thymol protects against bleomycin-induced pulmonary fibrosis via abrogation of oxidative stress, inflammation, and modulation of miR-29a/TGF-β and PI3K/Akt …

RM Hussein, ESA Arafa, SA Raheem, WR Mohamed - Life sciences, 2023 - Elsevier
Idiopathic pulmonary fibrosis is a terminal lung ailment that shares several pathological and
genetic mechanisms with severe COVID-19. Thymol (THY) is a dietary compound found in …

[HTML][HTML] Mitochondrial dysfunction: A promising therapeutic target for liver diseases

P Chen, L Yao, M Yuan, Z Wang, Q Zhang, Y Jiang… - Genes & …, 2024 - Elsevier
The liver is an important metabolic and detoxification organ and hence demands a large
amount of energy, which is mainly produced by the mitochondria. Liver tissues of patients …

Protective effect of quercetin on avermectin induced splenic toxicity in carp: Resistance to inflammatory response and oxidative damage

E Pan, H Chen, X Wu, N He, J Gan, H Feng… - Pesticide Biochemistry …, 2023 - Elsevier
Avermectin pollution is an important problem that cannot be ignored in aquatic system in
recent years. It has brought great trouble to freshwater aquaculture, especially fishery …

Silymarin abrogates acrylamide‐induced oxidative stress‐mediated testicular toxicity via modulation of antioxidant mechanism, DNA damage, endocrine deficit and …

HA Alturki, HA Elsawy, AC Famurewa - Andrologia, 2022 - Wiley Online Library
Acrylamide (ACR) is a toxic chemical formed in foods processed at high temperature; it is a
food‐borne toxicant with increasing public health attention due to its carcinogenic …