The yeast cell wall is a highly dynamic structure that is responsible for protecting the cell
from rapid changes in external osmotic potential. The wall is also critical for cell expansion …

The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), 1 formed by
phosphorylation of sphingosine catalyzed by sphingosine kinase (Fig. 1), is an important …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

The mechanism of cholera toxin (CT) internalization has been investigated using Caco-2
cells transfected with caveolin to induce formation of caveolae, HeLa cells with inducible …

Eukaryotes are characterized by endomembranes that are connected by vesicular transport
along secretory and endocytic pathways. The compositional differences between the various …

We describe recent advances in understanding sphingolipid functions and metabolism in
the baker's yeast Saccharomyces cerevisiae. One milestone has been reached in yeast …

Sterols and sphingolipids are considered mainly eukaryotic lipids even though both are
present in some prokaryotes, with sphingolipids being more widespread than sterols. Both …

Production of the essential phospholipid PI4P at the Golgi by the Pik1 kinase is required for
protein secretion, while a distinct pool of PI4P generated by the Stt4 kinase is critical for …

SUMMARY The Bin1/amphiphysin/Rvs167 (BAR) domain proteins are a ubiquitous protein
family. Genes encoding members of this family have not yet been found in the genomes of …

Our understanding of sphingolipid metabolism and functions in the baker's yeast
Saccharomyces cerevisiae has progressed substantially in the past 2 years. Yeast …