The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …

Hirschsprung disease is defined by the absence of enteric neurons at the end of the bowel.
The enteric nervous system (ENS) is the intrinsic nervous system of the bowel and regulates …

The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse
functions, including motility and epithelial permeability. Perturbations in ENS development …

Autonomous regulation of the intestine requires the combined activity of functionally distinct
neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types …

The enteric nervous system (ENS) is derived from both the vagal and sacral component of
the neural crest (NC). Here, we present the derivation of sacral ENS precursors from human …

The enteric nervous system (ENS) is comprised of a network of neurons and glial cells that
are responsible for coordinating many aspects of gastrointestinal (GI) function. These cells …

Background & Aims Hirschsprung disease (HSCR) is a life-threatening birth defect in which
the distal colon is devoid of enteric neural ganglia. HSCR is treated by surgical removal of …

Most of the enteric nervous system derives from the “vagal” neural crest, lying at the level of
somites 1–7, which invades the digestive tract rostro-caudally from the foregut to the hindgut …

Cell therapy offers the potential to replace the missing enteric nervous system (ENS) in
patients with Hirschsprung disease (HSCR) and to restore gut function. The Schwann cell …

Enteric glia are a fascinating population of cells. Initially identified in the gut wall as the
“support” cells of the enteric nervous system, studies over the past 20 years have unveiled a …