Alzheimer's disease (AD) is a progressive and synaptic failure disease. Despite the many
years of research, AD still harbors many secrets. As more of the world's population grows …

Alzheimer's disease (AD) is a devastating disease characterized by synaptic and neuronal
loss in the elderly. Compelling evidence suggests that soluble amyloid-β peptide (Aβ) …

It is currently unclear how amyloid-β and tau deposition are linked to changes in synaptic
function and axonal structure over the course of Alzheimer's disease. Here, we assessed …

Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks
of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

The purpose of our study was to determine the toxic effects of hippocampal mutant APP and
amyloid beta (Aβ) in 12-month-old APP transgenic mice. Using rotarod and Morris water …

Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Alzheimer's disease (AD) is characterized by cognitive impairment, progressive
neurodegeneration and formation of amyloid-β (Aβ)-containing plaques and neurofibrillary …

Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD) neurons. In this
study, we explored the involvement of an abnormal mitochondrial dynamics by investigating …

Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This
hypothesis might explain the lack of correlation between amyloid plaques and memory …