Therapeutic vaccines for HPV-associated malignancies

C Smalley Rumfield, N Roller, ST Pellom… - ImmunoTargets and …, 2020 - Taylor & Francis
Human papillomavirus (HPV)-related malignancies are responsible for almost all cases of
cervical cancer in women, and over 50% of all cases of head and neck carcinoma …

Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins

AM Almeida, JA Queiroz, F Sousa, Â Sousa - Drug discovery today, 2019 - Elsevier
Highlights•Human papillomavirus (HPV) has a primordial role in the development of cervical
cancer.•Therapies currently available for cervical cancer treatment are reviewed.•The …

Plasmid DNA for therapeutic applications in cancer

DH Martínez-Puente, JJ Pérez-Trujillo… - Pharmaceutics, 2022 - mdpi.com
Recently, the interest in using nucleic acids for therapeutic applications has been
increasing. DNA molecules can be manipulated to express a gene of interest for gene …

A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner

XJ Chen, WF Wei, ZC Wang, N Wang, CH Guo… - Angiogenesis, 2021 - Springer
Lymphatic remodelling in the hypoxic tumour microenvironment (TME) is critically involved
in the metastasis of cervical squamous cell carcinoma (CSCC); however, its underlying …

Enhancing the effect of nucleic acid vaccines in the treatment of HPV-related cancers: an overview of delivery systems

IA de Moura, AJD Silva, LS de Macêdo, MCV Invenção… - Pathogens, 2022 - mdpi.com
Prophylactic vaccines against human papillomavirus (HPV) have proven efficacy in those
who have not been infected by the virus. However, they do not benefit patients with …

The Combination of Molecular Adjuvant CCL35.2 and DNA Vaccine Significantly Enhances the Immune Protection of Carassius auratus gibelio against CyHV-2 …

X Huo, C Fan, T Ai, J Su - Vaccines, 2020 - mdpi.com
Cyprinid herpesvirus 2 (CyHV-2) infection results in huge economic losses in gibel carp
(Carassius auratus gibelio) industry. In this study, we first constructed recombinant plasmids …

Targeted gene delivery therapies for cervical cancer

Á Áyen, Y Jimenez Martinez, H Boulaiz - Cancers, 2020 - mdpi.com
Despite being largely preventable through early vaccination and screening strategies,
cervical cancer is the most common type of gynecological malignancy worldwide and …

Using PAMPs and DAMPs as adjuvants in cancer vaccines

H Sun, W Hu, Y Yan, Z Zhang, Y Chen… - Human Vaccines & …, 2021 - Taylor & Francis
Immunotherapy for cancer has attracted considerable attention. As one of the
immunotherapeutics, tumor vaccines exert great potential for cancer immunotherapy. The …

4-1BBL as a mediator of cross-talk between innate, adaptive, and regulatory immunity against cancer

AG Martinez-Perez, JJ Perez-Trujillo… - International Journal of …, 2021 - mdpi.com
The ability of tumor cells to evade the immune system is one of the main challenges we
confront in the fight against cancer. Multiple strategies have been developed to counteract …

Recent advances in DNA vaccines against lung cancer: A mini review

T Huang, L Liu, Z Lv, K Zhao, Q Yi, J Zhang - Vaccines, 2022 - mdpi.com
Lung cancer is regarded as the major causes of patient death around the world. Although
the novel tumor immunotherapy has made great progress in the past decades, such as …