Compared with traditional 2D adherent cell culture, 3D spheroidal cell aggregates, or
spheroids, are regarded as more physiological, and this technique has been exploited in the …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …

▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Class II cytokine receptors were originally defined on the basis of sequence homologies in
the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and …

The continuous rise in skin cancer incidence highlights an imperative for improved skin
cancer prevention. Topical calcipotriol-plus–5-fluorouracil (calcipotriol-plus–5-FU) …

Due to their structural similarity, interleukin (IL)‐19, IL‐20, IL‐22, IL‐24 and IL‐26 were
combined with IL‐10 in the so‐called IL‐10 family. To expand the knowledge on IL‐19, IL …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

Undifferentiated cells and embryos express high levels of endogenous non-telomerase
reverse transcriptase (RT) of retroposon/retroviral origin. We previously found that RT …

First identified almost two decades ago as a novel gene differentially expressed in human
melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great …