Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
A silver bullet in a golden age of functional genomics: the impact of Agrobacterium-mediated transformation of fungi
The implementation of Agrobacterium tumefaciens as a transformation tool revolutionized
approaches to discover and understand gene functions in a large number of fungal species …
approaches to discover and understand gene functions in a large number of fungal species …
Forward and reverse genetic dissection of morphogenesis identifies filament-competent Candida auris strains
DJ Santana, TR O'Meara - Nature communications, 2021 - nature.com
Candida auris is an emerging healthcare-associated pathogen of global concern. Recent
reports have identified C. auris isolates that grow in cellular aggregates or filaments, often …
reports have identified C. auris isolates that grow in cellular aggregates or filaments, often …
Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides
The basidiomycete yeast Rhodosporidium toruloides (also known as Rhodotorula
toruloides) accumulates high concentrations of lipids and carotenoids from diverse carbon …
toruloides) accumulates high concentrations of lipids and carotenoids from diverse carbon …
Cryptococcus neoformans sexual reproduction is controlled by a quorum sensing peptide
X Tian, GJ He, P Hu, L Chen, C Tao, YL Cui… - Nature …, 2018 - nature.com
Bacterial quorum sensing is a well-characterized communication system that governs a
large variety of collective behaviours. By comparison, quorum sensing regulation in …
large variety of collective behaviours. By comparison, quorum sensing regulation in …
Establishment of genomic library technology mediated by non-homologous end joining mechanism in Yarrowia lipolytica
Q Bai, S Cheng, J Zhang, M Li, Y Cao… - Science China Life …, 2021 - Springer
Genomic variants libraries are conducive to obtain dominant strains with desirable
phenotypic traits. The non-homologous end joining (NHEJ), which enables foreign DNA …
phenotypic traits. The non-homologous end joining (NHEJ), which enables foreign DNA …
Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition
The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both
in size and composition, upon entering the host. This cell wall remodeling is essential for …
in size and composition, upon entering the host. This cell wall remodeling is essential for …
Cryptococcus neoformans Mating and Genetic Crosses
S Sun, SJ Priest, J Heitman - Current protocols in microbiology, 2019 - Wiley Online Library
The Cryptococcus pathogenic species complex is a group of opportunistic human fungal
pathogens that cause cryptococcal meningoencephalitis, an infection associated with …
pathogens that cause cryptococcal meningoencephalitis, an infection associated with …
Transcription factor Znf2 coordinates with the chromatin remodeling SWI/SNF complex to regulate cryptococcal cellular differentiation
Cellular differentiation is instructed by developmental regulators in coordination with
chromatin remodeling complexes. Much information about their coordination comes from …
chromatin remodeling complexes. Much information about their coordination comes from …
Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death
EJ Thak, SB Lee, S Xu-Vanpala, DJ Lee, SY Chung… - MBio, 2020 - Am Soc Microbiol
Cryptococcus neoformans is a human-pathogenic fungal pathogen that causes life-
threatening meningoencephalitis in immunocompromised individuals. To investigate the …
threatening meningoencephalitis in immunocompromised individuals. To investigate the …