Treatment strategies for cryptococcal infection: challenges, advances and future outlook

KR Iyer, NM Revie, C Fu, N Robbins… - Nature Reviews …, 2021 - nature.com
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

A silver bullet in a golden age of functional genomics: the impact of Agrobacterium-mediated transformation of fungi

A Idnurm, AM Bailey, TC Cairns, CE Elliott… - Fungal Biology and …, 2017 - Springer
The implementation of Agrobacterium tumefaciens as a transformation tool revolutionized
approaches to discover and understand gene functions in a large number of fungal species …

Forward and reverse genetic dissection of morphogenesis identifies filament-competent Candida auris strains

DJ Santana, TR O'Meara - Nature communications, 2021 - nature.com
Candida auris is an emerging healthcare-associated pathogen of global concern. Recent
reports have identified C. auris isolates that grow in cellular aggregates or filaments, often …

Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides

ST Coradetti, D Pinel, GM Geiselman, M Ito, SJ Mondo… - Elife, 2018 - elifesciences.org
The basidiomycete yeast Rhodosporidium toruloides (also known as Rhodotorula
toruloides) accumulates high concentrations of lipids and carotenoids from diverse carbon …

Cryptococcus neoformans sexual reproduction is controlled by a quorum sensing peptide

X Tian, GJ He, P Hu, L Chen, C Tao, YL Cui… - Nature …, 2018 - nature.com
Bacterial quorum sensing is a well-characterized communication system that governs a
large variety of collective behaviours. By comparison, quorum sensing regulation in …

Establishment of genomic library technology mediated by non-homologous end joining mechanism in Yarrowia lipolytica

Q Bai, S Cheng, J Zhang, M Li, Y Cao… - Science China Life …, 2021 - Springer
Genomic variants libraries are conducive to obtain dominant strains with desirable
phenotypic traits. The non-homologous end joining (NHEJ), which enables foreign DNA …

Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition

SK Esher, KS Ost, MA Kohlbrenner, KM Pianalto… - PLoS …, 2018 - journals.plos.org
The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both
in size and composition, upon entering the host. This cell wall remodeling is essential for …

Cryptococcus neoformans Mating and Genetic Crosses

S Sun, SJ Priest, J Heitman - Current protocols in microbiology, 2019 - Wiley Online Library
The Cryptococcus pathogenic species complex is a group of opportunistic human fungal
pathogens that cause cryptococcal meningoencephalitis, an infection associated with …

Transcription factor Znf2 coordinates with the chromatin remodeling SWI/SNF complex to regulate cryptococcal cellular differentiation

J Lin, Y Zhao, AR Ferraro, E Yang, ZA Lewis… - Communications …, 2019 - nature.com
Cellular differentiation is instructed by developmental regulators in coordination with
chromatin remodeling complexes. Much information about their coordination comes from …

Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death

EJ Thak, SB Lee, S Xu-Vanpala, DJ Lee, SY Chung… - MBio, 2020 - Am Soc Microbiol
Cryptococcus neoformans is a human-pathogenic fungal pathogen that causes life-
threatening meningoencephalitis in immunocompromised individuals. To investigate the …