Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II)
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …

Background Prediction of T cell immunogenicity is a topic of considerable interest, both in
terms of basic understanding of the mechanisms of T cells responses and in terms of …

Highlights•Two recent crystal structures show how DM interacts with MHCII proteins.•Studies
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …

HLA is a polymorphic antigen presenter which has provided valuable information on the
susceptibility of populations to viruses. Therefore, the study of HLA can reveal specific …

The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection
remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that …

Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely
used to assess the binding of peptides to MHC proteins, particularly within the structural …

Therapeutic protein products (TPPs) are of considerable value in the treatment of a variety of
diseases, including cancer, hemophilia, and autoimmune diseases. The success of TPP …

Distinct CD4+ T cell epitopes have been associated with spontaneous control of HIV-1
replication, but analysis of antigen-dependent factors that influence epitope selection is …