The molecular mechanisms that underlie the immune biology of anti-drug antibody formation following treatment with monoclonal antibodies
A Vaisman-Mentesh, M Gutierrez-Gonzalez… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …
however, the repeated administration of mAbs can be highly immunogenic. Drug …
Class II MHC antigen processing in immune tolerance and inflammation
MM Jurewicz, LJ Stern - Immunogenetics, 2019 - Springer
Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes
J Racle, J Michaux, GA Rockinger, M Arnaud… - Nature …, 2019 - nature.com
Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II)
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …
Predicting HLA CD4 immunogenicity in human populations
Background Prediction of T cell immunogenicity is a topic of considerable interest, both in
terms of basic understanding of the mechanisms of T cells responses and in terms of …
terms of basic understanding of the mechanisms of T cells responses and in terms of …
[HTML][HTML] HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation
ED Mellins, LJ Stern - Current opinion in immunology, 2014 - Elsevier
Highlights•Two recent crystal structures show how DM interacts with MHCII proteins.•Studies
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …
Protective HLA alleles against severe COVID-19: HLA-A* 68 as an ancestral protection allele in Tapachula-Chiapas, Mexico
S Hernández-Doño, RA Sánchez-González… - Clinical …, 2022 - Elsevier
HLA is a polymorphic antigen presenter which has provided valuable information on the
susceptibility of populations to viruses. Therefore, the study of HLA can reveal specific …
susceptibility of populations to viruses. Therefore, the study of HLA can reveal specific …
Identification of distinct immune cell subsets associated with asymptomatic infection, disease severity, and viral persistence in COVID-19 patients
X Wang, H Bai, J Ma, H Qin, Q Zeng, F Hu… - Frontiers in …, 2022 - frontiersin.org
The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection
remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that …
remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that …
Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes
Measurements of thermal stability by circular dichroism (CD) spectroscopy have been widely
used to assess the binding of peptides to MHC proteins, particularly within the structural …
used to assess the binding of peptides to MHC proteins, particularly within the structural …
Therapeutic outcomes, assessments, risk factors and mitigation efforts of immunogenicity of therapeutic protein products
Therapeutic protein products (TPPs) are of considerable value in the treatment of a variety of
diseases, including cancer, hemophilia, and autoimmune diseases. The success of TPP …
diseases, including cancer, hemophilia, and autoimmune diseases. The success of TPP …
[HTML][HTML] A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design
S Sengupta, J Zhang, MC Reed, J Yu… - The Journal of …, 2023 - ncbi.nlm.nih.gov
Distinct CD4+ T cell epitopes have been associated with spontaneous control of HIV-1
replication, but analysis of antigen-dependent factors that influence epitope selection is …
replication, but analysis of antigen-dependent factors that influence epitope selection is …