Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

Voltage-gated sodium channels open (activate) when the membrane is depolarized and
close on repolarization (deactivate) but also on continuing depolarization by a process …

A computational model of the human left-ventricular epicardial myocyte is presented. Models
of each of the major ionic currents present in these cells are formulated and validated using …

Voltage-gated sodium channels (Nav) are modulated by many bilayer mechanical
amphiphiles, but whether, like other voltage-gated channels (Kv, HCN, Cav), they respond to …

Markov models (MMs) represent a generalization of Hodgkin–Huxley models. They provide
a versatile structure for modelling single channel data, gating currents, state-dependent drug …

Mathematical models of ionic currents are used to study the electrophysiology of the heart,
brain, gut, and several other organs. Increasingly, these models are being used predictively …

Abstract Transient Receptor Potential (TRP) proteins are non-selective cationic channels
with a consistent Ca 2+-permeability, except for TRPM4 and TRPM5 that are not permeable …

Abstract Aims Long QT syndrome (LQTS) carries a risk of life-threatening polymorphic
ventricular tachycardia (Torsades de Pointes, TdP) and is a major cause of premature …

Voltage-dependent Na+ channels are crucial for electrical signalling in excitable cells.
Membrane depolarization initiates asynchronous movements in four non-identical voltage …

Objective: We reported an ultraslow late Na+ current (I NaL) in ventricular cardiomyocytes of
human hearts. I NaL has been implicated in regulation of action potential duration in normal …