The tripeptide glutathione plays important roles in many cell processes, including
differentiation, proliferation, and apoptosis; in fact, disorders in glutathione homeostasis are …

There is an emerging paradigm shift in oncology that seeks to emphasize molecularly
targeted approaches for cancer prevention and therapy. Chalcones (1, 3-diphenyl-2-propen …

A series of coumarin–chalcone hybrids have been synthesized and evaluated for their in
vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts …

Chalcones have been identified as interesting compounds with cytotoxicity, anti-
inflammatory and antioxidant properties. In the present study, simple methoxychalcones …

A series of novel chalcone-triazole derivatives were synthesized and screened for in vitro
anticancer activity on the human cancer cell lines IMR32 (neuroblastoma), HepG2 …

Epidemiologic studies have demonstrated an inverse association between flavonoid intake
and prostate cancer (PCa) risk. The East Asian diet is very high in flavonoids and …

Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted
increasing interest because of their broad spectrum of biological functions. This review …

Relationships between the structural characteristic of synthetic chalcones and their
antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2' …

Flavonoids are common dietary components with many health benefits shown through
epidemiological studies. However, the fact that flavonoids also act as pro-oxidants and …

Synthesis of a cytotoxic dihydrochalcone, first isolated from a traditional Amazonian
medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by a comprehensive …