[HTML][HTML] The dark proteome: translation from noncanonical open reading frames

BW Wright, Z Yi, JS Weissman, J Chen - Trends in Cell Biology, 2022 - cell.com
Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …

Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer

N Ebrahimi, S Parkhideh, S Samizade… - Cytokine & growth factor …, 2022 - Elsevier
The assertion that a significant portion of the mammalian genome has not been translated
and that non-coding RNA accounts for over half of polyadenylate RNA have received much …

LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations

Z Li, L Liu, C Feng, Y Qin, J Xiao… - Nucleic Acids …, 2023 - academic.oup.com
LncBook, a comprehensive resource of human long non-coding RNAs (lncRNAs), has been
used in a wide range of lncRNA studies across various biological contexts. Here, we present …

LncRNA as a multifunctional regulator in cancer multi-drug resistance

J He, S Zhu, X Liang, Q Zhang, X Luo, C Liu… - Molecular Biology …, 2021 - Springer
Background Malignant tumors have become the most dangerous disease in recent years.
Chemotherapy is the most effective treatment for this disease; however, the problem of drug …

Cancer-related micropeptides encoded by ncRNAs: Promising drug targets and prognostic biomarkers

S Setrerrahmane, M Li, A Zoghbi, X Lv, S Zhang… - Cancer letters, 2022 - Elsevier
An exciting emerging topic in the noncoding RNA (ncRNA) field is the discovery of short
peptides called micropeptides (≤ 100 amino acids), whose novel therapeutic opportunities …

Significance of lncRNA abundance to function

I Grammatikakis, A Lal - Mammalian Genome, 2022 - Springer
Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse cellular processes.
Although the vast majority of lncRNAs are expressed at lower levels compared to …

The largely unexplored biology of small proteins in pro‐and eukaryotes

R Steinberg, HG Koch - The FEBS journal, 2021 - Wiley Online Library
The large abundance of small open reading frames (smORFs) in prokaryotic and eukaryotic
genomes and the plethora of smORF‐encoded small proteins became only apparent with …

p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy

K Yang, Y Xiao, L Zhong, W Zhang, P Wang… - Cancer Gene …, 2023 - nature.com
Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through
various mechanisms such as transcription, translation, protein modification and RNA-protein …

[HTML][HTML] Comprehensive landscape and future perspectives of long noncoding RNAs (lncRNAs) in colorectal cancer (CRC): Based on a bibliometric analysis

J He, W Wu - Non-coding RNA Research, 2023 - Elsevier
This review aimed to use bibliometric analysis to sort out, analyze and summarize the
knowledge foundation and hot topics in the field of long noncoding RNAs (lncRNAs) in …

[HTML][HTML] CRISPR–Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading …

C Zheng, Y Wei, P Zhang, K Lin, D He, H Teng… - Nature Structural & …, 2023 - nature.com
Emerging evidence suggests that cryptic translation beyond the annotated translatome
produces proteins with developmental or physiological functions. However, functions of …