Myelinated nerve fibers have evolved to enable fast and efficient transduction of electrical
signals in the nervous system. To act as an electric insulator, the myelin sheath is formed as …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Oligodendrocytes are glial cells that populate the entire CNS after they have differentiated
from oligodendrocyte progenitor cells. From birth onward, oligodendrocytes initiate wrapping …

Many proteins contain disordered regions of low-sequence complexity, which cause aging-
associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like …

Central nervous system myelin is a multilayered membrane sheath generated by
oligodendrocytes for rapid impulse propagation. However, the underlying mechanisms of …

Myelin is required for rapid nerve signaling and is emerging as a key driver of CNS plasticity
and disease. How myelin is built and remodeled remains a fundamental question of …

Myelin is essential in vertebrates for the rapid propagation of action potentials, but the
molecular mechanisms driving its formation remain largely unknown. Here we show that the …

Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

The recent rapid accumulation of knowledge on the dynamics and structure of the plasma
membrane has prompted major modifications of the textbook fluid-mosaic model. However …

Although macroautophagy deficits are implicated across adult-onset neurodegenerative
diseases, we understand little about how the discrete, highly evolved cell types of the central …