Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

A sulfonamide is a functional group that is the basis of several sulfa drugs and thereby are
very much important scaffolds in medicinal as well as in synthetic organic chemistry …

Human genetic studies have implicated the voltage-gated sodium channel NaV1. 7 as a
therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated …

Abstract Na V 1.7, a subtype of the voltage-gated sodium channel family that is highly
expressed in peripheral sensory neurons, remains one of the most promising targets for the …

Pain places a devastating burden on patients and society and current pain therapeutics
exhibit limitations in efficacy, unwanted side effects and the potential for drug abuse and …

In 2006, humans with a congenital insensitivity to pain (CIP) were found to lack functional
NaV1. 7 channels. In the subsequent 15 years there was a rush to develop selective …

A series of acidic diaryl ether heterocyclic sulfonamides that are potent and subtype
selective NaV1. 7 inhibitors is described. Optimization of early lead matter focused on …

The voltage-gated sodium (Na V) channel Na V 1.7 has been identified as a potential novel
analgesic target due to its involvement in human pain syndromes. However, clinically …

High‐throughput synthesis and screening of chemical libraries play pivotal roles in drug
discovery. Click chemistry has emerged as a powerful strategy for constructing highly …

Toxins and venom components that target voltage-gated sodium (Na V) channels have
evolved numerous times due to the importance of this class of ion channels in the normal …