Quadruplex nucleic acids as targets for anticancer therapeutics
S Neidle - Nature Reviews Chemistry, 2017 - nature.com
Quadruplex nucleic acids—helical four-stranded structures known to form from guanine-rich
nucleic acid sequences through Hoogsteen-type hydrogen bonding—were once just …
nucleic acid sequences through Hoogsteen-type hydrogen bonding—were once just …
G-quadruplexes in c-MYC promoter as targets for cancer therapy
Cancer is a societal burden demanding innovative approaches. A major problem with the
conventional chemotherapeutic agents is their strong toxicity and other side effects due to …
conventional chemotherapeutic agents is their strong toxicity and other side effects due to …
Design of Modular G‐quadruplex Ligands
AR Duarte, E Cadoni, AS Ressurreição… - …, 2018 - Wiley Online Library
Guanine‐rich nucleic acid sequences able to form four‐stranded structures (G‐
quadruplexes, G4) play key cellular regulatory roles and are considered as promising drug …
quadruplexes, G4) play key cellular regulatory roles and are considered as promising drug …
[HTML][HTML] Major achievements in the design of quadruplex-interactive small molecules
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …
acids have great potential as selective drugs or as tools in drug target discovery programs …
The remodel of the “central dogma”: a metabolomics interaction perspective
G Costa dos Santos, M Renovato-Martins, NM de Brito - Metabolomics, 2021 - Springer
Abstract Background In 1957, Francis Crick drew a linear diagram on a blackboard. This
diagram is often called the “central dogma.” Subsequently, the relationships between …
diagram is often called the “central dogma.” Subsequently, the relationships between …
Structure of two G-quadruplexes in equilibrium in the KRAS promoter
J Marquevielle, C Robert, O Lagrabette… - Nucleic Acids …, 2020 - academic.oup.com
KRAS is one of the most mutated oncogenes and still considered an undruggable target. An
alternative strategy would consist in targeting its gene rather than the protein, specifically the …
alternative strategy would consist in targeting its gene rather than the protein, specifically the …
Potential roles for G-quadruplexes in mitochondria
Some DNA or RNA sequences rich in guanine (G) nucleotides can adopt noncanonical
conformations known as G-quadruplexes (G4). In the nuclear genome, G4 motifs have been …
conformations known as G-quadruplexes (G4). In the nuclear genome, G4 motifs have been …
Exploring the Relationship between G-Quadruplex Nucleic Acids and Plants: From Plant G-Quadruplex Function to Phytochemical G4 Ligands with Pharmaceutic …
G-quadruplex (G4) oligonucleotides are higher-order DNA and RNA secondary structures of
enormous relevance due to their implication in several biological processes and …
enormous relevance due to their implication in several biological processes and …
G-Quadruplex Modulation of SP1 Functional Binding Sites at the KIT Proximal Promoter
S Da Ros, G Nicoletto, R Rigo, S Ceschi… - International journal of …, 2020 - mdpi.com
The regulation of conformational arrangements of gene promoters is a physiological
mechanism that has been associated with the fine control of gene expression. Indeed, it can …
mechanism that has been associated with the fine control of gene expression. Indeed, it can …
Targeting a noncanonical, hairpin-containing G-quadruplex structure from the MYCN gene
The MYCN gene encodes the transcription factor N-Myc, a driver of neuroblastoma (NB).
Targeting G-quadruplexes (G4s) with small molecules is attractive strategy to control the …
Targeting G-quadruplexes (G4s) with small molecules is attractive strategy to control the …