Drug repurposing for cancer therapy
Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …
health. Despite significant advances in surgical, radiotherapeutic and immunological …
[HTML][HTML] Role of E2F transcription factor in oral cancer: Recent insight and advancements
A Kassab, I Gupta, AE Al Moustafa - Seminars in cancer biology, 2023 - Elsevier
The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …
Cancer signature ensemble integrating cfDNA methylation, copy number, and fragmentation facilitates multi-cancer early detection
SY Kim, S Jeong, W Lee, Y Jeon, YJ Kim… - … & molecular medicine, 2023 - nature.com
Cell-free DNA (cfDNA) sequencing has demonstrated great potential for early cancer
detection. However, most large-scale studies have focused only on either targeted …
detection. However, most large-scale studies have focused only on either targeted …
Aging and Age-related epigenetic drift in the pathogenesis of leukemia and lymphomas: new therapeutic targets
One of the traits of cancer cells is abnormal DNA methylation patterns. The idea that age-
related epigenetic changes may partially explain the increased risk of cancer in the elderly is …
related epigenetic changes may partially explain the increased risk of cancer in the elderly is …
[HTML][HTML] Whole organism aging: Parabiosis, inflammaging, epigenetics, and peripheral and central aging clocks. The ARS of aging
The strong interest shown in the study of the causes of aging in recent decades has
uncovered many mechanisms that could contribute to the rate of aging. These include …
uncovered many mechanisms that could contribute to the rate of aging. These include …
[HTML][HTML] Combination of the biomarkers for aging and cancer?-Challenges and current status
D Li, F Ju, H Wang, C Fan, JC Jacob, S Gul… - Translational …, 2023 - Elsevier
The proportion of patients diagnosed with cancer has been shown to rise with the increasing
aging global population. Advanced age is a major risk factor for morbidity and mortality in …
aging global population. Advanced age is a major risk factor for morbidity and mortality in …
A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment
RF Pérez, P Tezanos, A Peñarroya… - Nature …, 2024 - nature.com
Aging involves the deterioration of organismal function, leading to the emergence of multiple
pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this …
pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this …
Inflammation, Infiltration, and Evasion—Tumor Promotion in the Aging Breast
N Cruz-Reyes, DC Radisky - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer is a significant health problem affecting millions of women
worldwide, particularly post-menopausal women. Although early detection and treatment …
worldwide, particularly post-menopausal women. Although early detection and treatment …
Biological Aging Acceleration Due to Environmental Exposures: An Exciting New Direction in Toxicogenomics Research
Biological clock technologies are designed to assess the acceleration of biological age (B-
age) in diverse cell types, offering a distinctive opportunity in toxicogenomic research to …
age) in diverse cell types, offering a distinctive opportunity in toxicogenomic research to …
Clinical significance of tumor suppressor genes methylation in circulating tumor DNA of patients with pancreatic cancer
WP Xin, S Tu, S Yi, Y Xiong, K Fang, G Sun, W Xiao - Gene, 2024 - Elsevier
Abstract Background Circulating tumor DNA (ctDNA) has emerged as a potential diagnostic
and prognostic biomarker in various tumors. However, the role of tumor suppressor genes …
and prognostic biomarker in various tumors. However, the role of tumor suppressor genes …