Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
AN Brandebura, A Paumier, TS Onur… - Nature Reviews …, 2023 - nature.com
There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …
[HTML][HTML] Behaviorally consequential astrocytic regulation of neural circuits
Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …
throughout nervous systems of multiple species. Progress over the last two decades has …
Molecular basis of astrocyte diversity and morphology across the CNS in health and disease
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …
Cell2location maps fine-grained cell types in spatial transcriptomics
Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in
health and disease, but comprehensive mapping of cell types in situ remains a challenge …
health and disease, but comprehensive mapping of cell types in situ remains a challenge …
[HTML][HTML] Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish
Biological computing (or biocomputing) offers potential advantages over silicon-based
computing in terms of faster decision-making, continuous learning during tasks, and greater …
computing in terms of faster decision-making, continuous learning during tasks, and greater …
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition
in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology …
in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology …
Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease
S Hijazi, AB Smit, RE van Kesteren - Molecular Psychiatry, 2023 - nature.com
Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …
morphological and functional properties that allow them to precisely control local circuitry …
Molecular and metabolic heterogeneity of astrocytes and microglia
Astrocytes and microglia are central players in a myriad of processes in the healthy and
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …
Human Alzheimer's disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain's major cell types and are responsible for maintaining
neuronal homeostasis via regulating the extracellular environment, providing metabolic …
neuronal homeostasis via regulating the extracellular environment, providing metabolic …
A closer look at astrocyte morphology: Development, heterogeneity, and plasticity at astrocyte leaflets
B Torres-Ceja, ML Olsen - Current opinion in neurobiology, 2022 - Elsevier
Astrocytes represent an abundant type of glial cell involved in nearly every aspect of central
nervous system (CNS) function, including synapse formation and maturation, ion and …
nervous system (CNS) function, including synapse formation and maturation, ion and …