Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

AN Brandebura, A Paumier, TS Onur… - Nature Reviews …, 2023 - nature.com
There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

[HTML][HTML] Behaviorally consequential astrocytic regulation of neural circuits

J Nagai, X Yu, T Papouin, E Cheong, MR Freeman… - Neuron, 2021 - cell.com
Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

F Endo, A Kasai, JS Soto, X Yu, Z Qu, H Hashimoto… - Science, 2022 - science.org
Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report
astrocyte molecular profiles, diversity, and morphology across the mouse central nervous …

Cell2location maps fine-grained cell types in spatial transcriptomics

V Kleshchevnikov, A Shmatko, E Dann… - Nature …, 2022 - nature.com
Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in
health and disease, but comprehensive mapping of cell types in situ remains a challenge …

[HTML][HTML] Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

L Smirnova, BS Caffo, DH Gracias, Q Huang… - Frontiers in …, 2023 - frontiersin.org
Biological computing (or biocomputing) offers potential advantages over silicon-based
computing in terms of faster decision-making, continuous learning during tasks, and greater …

An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology

PW Sheehan, CJ Nadarajah, MF Kanan, JN Patterson… - Neuron, 2023 - cell.com
The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition
in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology …

Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease

S Hijazi, AB Smit, RE van Kesteren - Molecular Psychiatry, 2023 - nature.com
Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Molecular and metabolic heterogeneity of astrocytes and microglia

P Hasel, WH Aisenberg, FC Bennett, SA Liddelow - Cell Metabolism, 2023 - cell.com
Astrocytes and microglia are central players in a myriad of processes in the healthy and
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …

Human Alzheimer's disease reactive astrocytes exhibit a loss of homeostastic gene expression

DL Dai, M Li, EB Lee - Acta Neuropathologica Communications, 2023 - Springer
Astrocytes are one of the brain's major cell types and are responsible for maintaining
neuronal homeostasis via regulating the extracellular environment, providing metabolic …

A closer look at astrocyte morphology: Development, heterogeneity, and plasticity at astrocyte leaflets

B Torres-Ceja, ML Olsen - Current opinion in neurobiology, 2022 - Elsevier
Astrocytes represent an abundant type of glial cell involved in nearly every aspect of central
nervous system (CNS) function, including synapse formation and maturation, ion and …