Predictive biomarkers for immunotherapy in lung cancer: perspective from the international association for the study of lung cancer pathology committee

M Mino-Kenudson, K Schalper, W Cooper… - Journal of Thoracic …, 2022 - Elsevier
Immunotherapy including immune checkpoint inhibitors (ICIs) has become the backbone of
treatment for most lung cancers with advanced or metastatic disease. In addition, they have …

Biomarkers for immune checkpoint inhibitor response in NSCLC: current developments and applicability

K Tostes, AP Siqueira, RM Reis, LF Leal… - International Journal of …, 2023 - mdpi.com
Lung cancer has the highest mortality rate among all cancer types, resulting in over 1.8
million deaths annually. Immunotherapy utilizing immune checkpoint inhibitors (ICIs) has …

Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer

R Thummalapalli, B Ricciuti, C Bandlamudi… - Clinical Cancer …, 2023 - AACR
Purpose: We sought to identify features of patients with advanced non–small cell lung
cancer (NSCLC) who achieve long-term response (LTR) to immune checkpoint inhibitors …

Association between survival and very high versus high PD-L1 expression in patients receiving pembrolizumab as first-line treatment for advanced non-small cell lung …

M Shah, ME Marmarelis, R Mamtani, S Hennessy - Clinical Lung Cancer, 2022 - Elsevier
Background A prior study found that, among advanced non-small cell lung cancer
(aNSCLC) patients with PD-L1 expression 50% to 100% receiving immunotherapy as …

[HTML][HTML] Tobacco exposure primes the secretion of CCL21 positively associated with tertiary lymphoid structure and response to immunotherapy

X Yin, H Wang, R Li, X Song, T Zhang… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background It has been reported that smoking history as a predictor of immunotherapy
efficacy in patients with advanced lung cancer, however, the underlying mechanisms of this …

[HTML][HTML] Applications of circulating tumor DNA in immune Checkpoint inhibition: emerging roles and future perspectives

C Lu, YC Zhang, ZH Chen, Q Zhou, YL Wu - Frontiers in Oncology, 2022 - frontiersin.org
Immune checkpoint inhibitors (ICIs), especially anti-PD-1/PD-L1 antibodies, have made
dramatic progress in treatment of lung cancer, especially for non-oncogene driven patients …

Predictive capability of PD-L1 protein expression for patients with advanced NSCLC: Any differences based on histology?

N Meshulami, S Tavolacci, D de Miguel-Perez… - Clinical Lung Cancer, 2023 - Elsevier
Lung cancer is responsible for 1.8 million annual deaths. Non-small cell lung cancers
(NSCLC) represent 85% of lung cancer tumors. While surgery is an effective early-stage …

Smoking status at time of diagnosis affects the efficacy of anti-PD-1/L1 therapy in patients with advanced NSCLC

KY Kim, JU Lim, HS Kang, JS Kim, SK Kim, SJ Kim… - in vivo, 2023 - iv.iiarjournals.org
Background/Aim: Programmed death ligand-1 (PD-L1) expression is known to be a
predictive biomarker for response to immunotherapy in non-small cell lung cancer (NSCLC) …

Effect of PD-L1 expression for the PD-1/L1 inhibitors on non-small cell lung cancer: a meta-analysis based on randomised controlled trials

Z Xu, J Liang, R Fu, L Yang, YX Chen, W Ren, Y Lu… - Clinical Oncology, 2023 - Elsevier
Abstract Aims As PD-L1 expression has been proposed as one of the cancer biomarkers for
non-small cell lung cancer (NSCLC), the predictive value of tumour proportional score (TPS) …

Baseline C-reactive protein predicts efficacy of the first-line immune checkpoint inhibitors plus chemotherapy in advanced lung squamous cell carcinoma: a …

X Zheng, L Zhang, L Wu, J Zhao, J Sun, Y Fang, J Zhou… - BMC cancer, 2023 - Springer
Aims To investigate the predictive value of baseline C-reactive protein (CRP) levels on the
efficacy of chemotherapy plus immune checkpoint inhibitors (ICI) in patients with advanced …