Coronary calcium score and cardiovascular risk
Coronary artery calcium (CAC) is a highly specific feature of coronary atherosclerosis. On
the basis of single-center and multicenter clinical and population-based studies with short …
the basis of single-center and multicenter clinical and population-based studies with short …
Molecular mechanisms of vascular health: insights from vascular aging and calcification
Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
The Rotterdam Study: 2018 update on objectives, design and main results
MA Ikram, GGO Brusselle, SD Murad… - European journal of …, 2017 - Springer
Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting
Background: Relative risk reduction with statin therapy has been consistent across nearly all
subgroups studied to date. However, in analyses of 2 randomized controlled primary …
subgroups studied to date. However, in analyses of 2 randomized controlled primary …
[HTML][HTML] A genetic variant associated with five vascular diseases is a distal regulator of endothelin-1 gene expression
RM Gupta, J Hadaya, A Trehan, SM Zekavat, C Roselli… - Cell, 2017 - cell.com
Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for
five vascular diseases, including coronary artery disease, migraine headache, cervical …
five vascular diseases, including coronary artery disease, migraine headache, cervical …
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …
ADAMTS proteins in human disorders
TJ Mead, SS Apte - Matrix Biology, 2018 - Elsevier
ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …
Ischemic outcomes after coronary intervention of calcified vessels in acute coronary syndromes: pooled analysis from the HORIZONS-AMI (Harmonizing Outcomes …
P Généreux, MV Madhavan, GS Mintz… - Journal of the American …, 2014 - jacc.org
Objectives: This study sought to determine the frequency and impact of coronary calcification
among patients undergoing percutaneous coronary intervention (PCI) for acute coronary …
among patients undergoing percutaneous coronary intervention (PCI) for acute coronary …
Coronary artery calcification: pathogenesis and prognostic implications
MV Madhavan, M Tarigopula, GS Mintz… - Journal of the American …, 2014 - jacc.org
Coronary artery calcification (CAC) is a risk factor for adverse outcomes in the general
population and in patients with coronary artery disease. The pathogenesis of CAC and bone …
population and in patients with coronary artery disease. The pathogenesis of CAC and bone …
The Rotterdam Study: 2016 objectives and design update
A Hofman, GGO Brusselle, SD Murad… - European journal of …, 2015 - Springer
Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …