The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …

Chromosome stability requires a dynamic balance of DNA loss and gain in each terminal
tract of telomeric repeats. Repeat addition by a specialized reverse transcriptase …

Constitutive expression of telomerase in human cells prevents the onset of senescence and
crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that …

Telomerase activity is essential for human cancer cells in order to maintain telomeres and
provide unlimited proliferation potential and cellular immortality. However, additional non …

Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as
the nucleus, but details about its biology and function in the organelle remain largely …

Maintenance of telomeres by the enzyme telomerase is essential for genomic stability and
cell viability in ciliates, vertebrates and yeast. The minimal components of telomerase …

Telomerase activity is responsible for the maintenance of chromosome end structures
(telomeres) and cancer cell immortality in most human malignancies, making telomerase an …

Telomerase, a ribonucleoprotein enzyme, adds telomeric DNA repeats to the ends of linear
chromosomes. Here we report the first high-resolution structure of any portion of the …

Telomeres are terminal repetitive DNA sequences on chromosomes, and are considered to
comprise almost exclusively hexameric TTAGGG repeats. We have evaluated telomere …

Telomerase canonical activity at telomeres prevents telomere shortening, allowing
chromosome stability and cellular proliferation. To perform this task, the catalytic subunit …