Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …

There is a continued desire in biomedical research to reduce the number and duration of
design cycles required to optimize lead compounds into high-quality chemical probes or …

During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …

Over the last twenty years, fluorination on nucleoside has established itself as the most
promising tool to use to get biologically active compounds that could sustain the clinical trial …

A photocatalytic three-component reaction of α-trifluoromethyl alkenes, electron-rich
alkenes, and sodium sulfinates for the synthesis of gem-difluoroalkenes in a radical/polar …

The 6′-fluorinated aristeromycins were designed as dual-target antiviral compounds aimed
at inhibiting both the viral RNA-dependent RNA polymerase (RdRp) and the host cell S …

Nucleoside analogues are at the forefront of antiviral therapy for last decades. To circumvent
some of their limitations, based on their metabolism, and in order to improve their anti‐viral …

Highlights•This review mainly summarizes the anti-cancer effects of adenosine analogues in
market and clinical trials.•This review describes the anti-cancer strategies and mechanisms …

Alphaviruses are arthropod-borne, positive-stranded RNA viruses capable of causing
severe disease with high morbidity. Chikungunya virus (CHIKV) is an alphavirus that causes …

Based on the potent anticancer activity of 6′-fluorocyclopentenyl-cytosine 2b in phase IIa
clinical trials for the treatment of gemcitabine-resistant pancreatic cancer, we carried out a …