snRNAs as the catalysts of pre-mRNA splicing
S Valadkhan - Current opinion in chemical biology, 2005 - Elsevier
The spliceosome, the gigantic molecular machine that performs pre-mRNA splicing in
eukaryotes, contains over 200 different proteins and five RNA molecules. The central role …
eukaryotes, contains over 200 different proteins and five RNA molecules. The central role …
Review NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings
M Getz, X Sun, A Casiano‐Negroni… - Biopolymers …, 2007 - Wiley Online Library
An increasing number of RNAs are being discovered that perform their functions by
undergoing large changes in conformation in response to a variety of cellular signals …
undergoing large changes in conformation in response to a variety of cellular signals …
RNA helical packing in solution: NMR structure of a 30 kDa GAAA tetraloop–receptor complex
JH Davis, M Tonelli, LG Scott, L Jaeger… - Journal of molecular …, 2005 - Elsevier
Tertiary interactions are critical for proper RNA folding and ribozyme catalysis. RNA tertiary
structure is often condensed through long-range helical packing interactions mediated by …
structure is often condensed through long-range helical packing interactions mediated by …
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
Intron removal in nuclear precursor mRNA is catalyzed through two transesterification
reactions by a multi-megaDalton ribonucleoprotein machine called the spliceosome. A …
reactions by a multi-megaDalton ribonucleoprotein machine called the spliceosome. A …
Structure of the yeast U2/U6 snRNA complex
The U2/U6 snRNA complex is a conserved and essential component of the active
spliceosome that interacts with the pre-mRNA substrate and essential protein splicing …
spliceosome that interacts with the pre-mRNA substrate and essential protein splicing …
Solution structure and thermodynamic investigation of the HIV-1 frameshift inducing element
DW Staple, SE Butcher - Journal of molecular biology, 2005 - Elsevier
Expression of the HIV reverse transcriptase and other essential viral enzymes requires a− 1
translational frameshift. The frameshift event is induced by two highly conserved RNA …
translational frameshift. The frameshift event is induced by two highly conserved RNA …
Solution structure of the HIV‐1 frameshift inducing stem–loop RNA
DW Staple, SE Butcher - Nucleic acids research, 2003 - academic.oup.com
The translation of reverse transcriptase and other essential viral proteins from the HIV‐1 Pol
mRNA requires a programmed–1 ribosomal frameshift. This frameshift is induced by two …
mRNA requires a programmed–1 ribosomal frameshift. This frameshift is induced by two …
Characterizing excited conformational states of RNA by NMR spectroscopy
B Zhao, Q Zhang - Current opinion in structural biology, 2015 - Elsevier
Highlights•RNA molecules undergo complex conformational transitions to perform diverse
functions.•Novel NMR methods have enabled characterization of excited states in diverse …
functions.•Novel NMR methods have enabled characterization of excited states in diverse …
Single-molecule analysis of protein-free U2–U6 snRNAs
Spliceosomes catalyze the maturation of precursor mRNAs in organisms ranging from yeast
to humans. Their catalytic core comprises three small nuclear RNAs (U2, U5 and U6) …
to humans. Their catalytic core comprises three small nuclear RNAs (U2, U5 and U6) …
Towards understanding the catalytic core structure of the spliceosome
SE Butcher, DA Brow - Biochemical Society Transactions, 2005 - portlandpress.com
The spliceosome catalyses the splicing of nuclear pre-mRNA (precursor mRNA) in
eukaryotes. Pre-mRNA splicing is essential to remove internal non-coding regions of pre …
eukaryotes. Pre-mRNA splicing is essential to remove internal non-coding regions of pre …