Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

The common marmoset (Callithrix jacchus) is increasingly attractive for use as a non-human
primate animal model in biomedical research. It has a relatively high reproduction rate for a …

The capacity to efficiently transduce nondividing cells, shuttle large genetic payloads, and
maintain stable long-term transgene expression are attributes that have brought lentiviral …

Crucial prerequisites for the development of safe preclinical protocols in biomedical
research are suitable animal models that would allow for human‐related validation of …

The translation of novel discoveries from basic research to clinical application is a long,
often inefficient, and thus costly process. Accordingly, the process of drug development …

Retrovirus vectors integrate into the genome, providing stable gene transfer, but integration
contributes in part to transcriptional silencing that compromises long-term expression. In the …

An effective method for genetic modification of chickens has yet to be developed. An efficient
technology, enabling production of transgenic birds at high frequency and with reliable …

Transgenic pigs are promising donor organisms for xenotransplantation as they share many
anatomical and physiological characteristics with humans. The most profound barrier to pig …

Genetically modified swine hold great promise in the fields of agriculture and medicine.
Currently, these swine are being used to optimize production of quality meat, to improve our …