Targeting the prion-like aggregation of mutant p53 to combat cancer
Conspectus Prion-like behavior of several amyloidogenic proteins has been demonstrated
in recent years. Despite having functional roles in some cases, irregular aggregation can …
in recent years. Despite having functional roles in some cases, irregular aggregation can …
[HTML][HTML] Recent synthetic approaches towards small molecule reactivators of p53
The tumor suppressor protein p53 is often called “the genome guardian” and controls the
cell cycle and the integrity of DNA, as well as other important cellular functions. Its main …
cell cycle and the integrity of DNA, as well as other important cellular functions. Its main …
Synthesis, antimicrobial and cytotoxic activities of pyrimidinyl benzoxazole, benzothiazole and benzimidazole
D Seenaiah, PR Reddy, GM Reddy, A Padmaja… - European Journal of …, 2014 - Elsevier
A variety of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles linked by thio,
methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic …
methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic …
Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties
SR Punganuru, HR Madala, SN Venugopal… - European journal of …, 2016 - Elsevier
Small molecules that can restore biological function to the p53 mutants found in human
cancers have been highly sought to increase the anticancer efficacy. In efforts to generate …
cancers have been highly sought to increase the anticancer efficacy. In efforts to generate …
Microsecond molecular dynamics simulations reveal the allosteric regulatory mechanism of p53 R249S mutation in p53-associated liver cancer
X Liu, W Tian, J Cheng, D Li, T Liu, L Zhang - Computational biology and …, 2020 - Elsevier
The tumor suppressor p53, a transcription factor, plays a critical role in many cellular
processes, including DNA repair and apoptosis and cell cycle arrest. Missense mutations in …
processes, including DNA repair and apoptosis and cell cycle arrest. Missense mutations in …
Selective killing of human breast cancer cells by the styryl lactone (R)-goniothalamin is mediated by glutathione conjugation, induction of oxidative stress and marked …
The molecular basis of anticancer and apoptotic effects of R-goniothalamin (GON), a plant
secondary metabolite was studied. We show that induction of oxidative stress and …
secondary metabolite was studied. We show that induction of oxidative stress and …
Unusual Epimerization in Styryllactones: Synthesis of (−)-5-Hydroxygoniothalamin, (−)-5-Acetylgoniothalamin, and O-TBS-Goniopypyrone
TK Kotammagari, S Paul, AK Bhattacharya - ACS omega, 2019 - ACS Publications
(−)-5-Hydroxygoniothalamin,(−)-5-acetylgoniothalamin, and (+)-5-hydroxygoniothalamin,
isolated from the Goniothalamus genus, are synthesized from triacetyl-Od-glucal by …
isolated from the Goniothalamus genus, are synthesized from triacetyl-Od-glucal by …
Stereocontrolled Synthesis of Highly Substituted trans α,β‐Unsaturated Ketones with Potent Anticancer Properties from Glycals
P Jovanovic, M Petkovic, M Simic… - European Journal of …, 2019 - Wiley Online Library
A novel synthetic route for highly substituted conjugated ketones has been developed
utilizing glycals as starting materials. The two‐step process combined the Heck …
utilizing glycals as starting materials. The two‐step process combined the Heck …
Small molecules to enhance P53 activity
US9737546B2 - Small molecules to enhance P53 activity - Google Patents US9737546B2 -
Small molecules to enhance P53 activity - Google Patents Small molecules to enhance P53 …
Small molecules to enhance P53 activity - Google Patents Small molecules to enhance P53 …
[图书][B] The Molecular Basis for Restoring Function to Oncogenic p53 Mutants
BD Wallentine - 2016 - search.proquest.com
The tumor suppressor p53 is the most commonly mutated gene in cancers, with
approximately half of all tumors containing a p53 mutation. p53 normally functions to …
approximately half of all tumors containing a p53 mutation. p53 normally functions to …