Novel drug developmental strategies for treatment‐resistant depression
Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …
therapies are ineffective in many patients, novel strategies are needed to overcome …
[HTML][HTML] Statins in depression: an evidence-based overview of mechanisms and clinical studies
R De Giorgi, N Rizzo Pesci, A Quinton… - Frontiers in …, 2021 - frontiersin.org
Background: Depression is a leading cause of disability, burdened by high levels of non-
response to conventional antidepressants. Novel therapeutic strategies targeting non …
response to conventional antidepressants. Novel therapeutic strategies targeting non …
The pharmacological bases for repurposing statins in depression: a review of mechanistic studies
Statins are commonly prescribed medications widely investigated for their potential actions
on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may …
on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may …
The antidepressant-like effect of doxycycline is associated with decreased nitric oxide metabolite levels in the prefrontal cortex
Doxycycline is an antibiotic that has shown neuroprotective, anti-inflammatory, and
antidepressant-like effects. Low doses of doxycycline revert the behavioral and …
antidepressant-like effects. Low doses of doxycycline revert the behavioral and …
Electroacupuncture relieves LPS-induced depression-like behaviour in rats through IDO-mediated tryptophan-degrading pathway
K Zhang, R Liu, Y Gao, W Ma… - … Disease and Treatment, 2020 - Taylor & Francis
Background Neuroinflammation is an important pathological mechanism of depression that
leads to an increase in indoleamine-2, 3-dioxygenase (IDO) activity and NMDAR activation …
leads to an increase in indoleamine-2, 3-dioxygenase (IDO) activity and NMDAR activation …
The effect of montelukast, a leukotriene receptor antagonist, on the acetic acid-induced model of colitis in rats: Involvement of NO-cGMP-KATP channels pathway
B Ghorbanzadeh, MA Behmanesh… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease is a chronic autoimmune disorder that may involve entire
gastrointestinal tract. The leukotrienes have a role as mediators in the pathophysiology of …
gastrointestinal tract. The leukotrienes have a role as mediators in the pathophysiology of …
Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor
XB Yu, KL Zhong, C Chen, J Fu, F Chen, HM Zhou… - …, 2024 - Springer
Background In our previous study, we showed simvastatin exerts an antidepressant effect
and inhibits neuroinflammation. Given the role of synaptic impairment in depression …
and inhibits neuroinflammation. Given the role of synaptic impairment in depression …
Involvement of agmatine in antidepressant-like effect of HMG-CoA reductase inhibitors in mice
S Rahangdale, R Fating, M Gajbhiye, M Kapse… - European Journal of …, 2021 - Elsevier
Hydroxy-3-methyl-glutaryl-co-enzyme–A (HMG-CoA) reductase inhibitors (statins) are
popularly used for the treatment of obesity and hypercholesterolemia with established safety …
popularly used for the treatment of obesity and hypercholesterolemia with established safety …
Combined inorganic nitrate/nitrite supplementation blunts α-mediated vasoconstriction during exercise in patients with type 2 diabetes
Aims Patients with type 2 diabetes mellitus (T2DM) have reduced vasodilatory responses
during exercise partially attributable to low nitric oxide (NO) levels. Low NO contributes to …
during exercise partially attributable to low nitric oxide (NO) levels. Low NO contributes to …
Aqueous extract of pomegranate enriched in ellagitannins prevents anxiety-like behavior and metabolic changes induced by cafeteria diet in an animal model of …
EM Estrada-Camarena, C López-Rubalcava… - Neurochemistry …, 2020 - Elsevier
Women around menopause are vulnerable to present psychiatric and metabolic disorders;
thus, therapies that contribute to treat both pathologies are required. Previous reports …
thus, therapies that contribute to treat both pathologies are required. Previous reports …