Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

Akt is a protein serine/threonine kinase that is involved in the regulation of diverse cellular
processes. Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

The serine/threonine protein phosphatases are targeted to specific subcellular locations and
substrates in part via interactions with a wide variety of regulatory proteins. Understanding …

The SV40 small t antigen (ST) interacts with the serine-threonine protein phosphatase 2A
(PP2A). To investigate the role of this interaction in transformation, we suppressed the …

Protein phosphatase type 2A (PP2A) enzymes constitute a large family of Ser/Thr
phosphatases with multiple functions in cellular signaling and physiology. The composition …

Mitochondrial shape is determined by fission and fusion reactions, perturbation of which can
contribute to neuronal injury and disease. Mitochondrial fission is catalyzed by dynamin …

Protein phosphatase 2A (PP2A) is a family of multifunctional serine/threonine phosphatases
all composed of a catalytic C, a structural A, and a regulatory B subunit. Assembly of the …