This systematic review aims to summarize cognitive reserve (CR) evaluation approaches
and to examine the role of seven selected modifiable lifestyle factors (diet, smoking, alcohol …

Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Preventing or delaying Alzheimer disease (AD) through lifestyle interventions will come from
a better understanding of the mechanistic underpinnings of (1) why a significant proportion …

Abstract Purpose of Review The aim of this review is to summarize current conceptual
models of cognitive reserve (CR) and related concepts and to discuss evidence for these …

Although the two pathological hallmarks of Alzheimer's disease (AD), senile plaques
composed of amyloid-β (Aβ) peptides and neurofibrillary tangles (NFTs) consisting of …

Objective To examine the associations of physical activity, Alzheimer disease (AD), and
other brain pathologies and cognition in older adults. Methods We studied 454 brain …

Background Cognitive reserve is most commonly measured using socio-behavioural proxy
variables. These variables are easy to collect, have a straightforward interpretation, and are …

Background: As adult brain structure is primarily established in early life, genetic and
environmental exposures in infancy and childhood influence the risk for Alzheimer disease …

Alzheimer's disease neuropathologic change (ADNC) is defined by progressive
accumulation of β-amyloid plaques and hyperphosphorylated tau (pTau) neurofibrillary …

The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …