[HTML][HTML] Advances in TRP channel drug discovery: from target validation to clinical studies

AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Regulation of pain and itch by TRP channels

C Moore, R Gupta, SE Jordt, Y Chen, WB Liedtke - Neuroscience bulletin, 2018 - Springer
Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine

B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data

F Jühling, H Kretzmer, SH Bernhart, C Otto… - Genome …, 2016 - genome.cshlp.org
The detection of differentially methylated regions (DMRs) is a necessary prerequisite for
characterizing different epigenetic states. We present a novel program, metilene, to identify …

[HTML][HTML] DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing

A Vidaki, D Ballard, A Aliferi, TH Miller… - Forensic Science …, 2017 - Elsevier
The ability to estimate the age of the donor from recovered biological material at a crime
scene can be of substantial value in forensic investigations. Aging can be complex and is …

TwinsUK: the UK adult twin registry update

S Verdi, G Abbasian, RCE Bowyer… - Twin Research and …, 2019 - cambridge.org
TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry
comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is …

Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation

PC Tsai, JT Bell - International journal of epidemiology, 2015 - academic.oup.com
Background: Epigenome-wide association scans (EWAS) are under way for many complex
human traits, but EWAS power has not been fully assessed. We investigate power of EWAS …

[HTML][HTML] Epigenetics of discordant monozygotic twins: implications for disease

JE Castillo-Fernandez, TD Spector, JT Bell - Genome medicine, 2014 - Springer
Monozygotic (MZ) twins share nearly all of their genetic variants and many similar
environments before and after birth. However, they can also show phenotypic discordance …

TRPA1: a molecular view

JE Meents, CI Ciotu… - Journal of …, 2019 - journals.physiology.org
The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing
neurons and other tissues and has become a major target in the development of novel …

TRPA1 channels: molecular sentinels of cellular stress and tissue damage

F Viana - The Journal of physiology, 2016 - Wiley Online Library
TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain
receptors, with a major role in chemonociception. TRPA1 has also been implicated in …