[HTML][HTML] Advances in TRP channel drug discovery: from target validation to clinical studies
AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
Regulation of pain and itch by TRP channels
Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …
pain perception. In this review, we discuss important experimental evidence involving some …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
B Nilius, A Szallasi - Pharmacological reviews, 2014 - ASPET
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data
The detection of differentially methylated regions (DMRs) is a necessary prerequisite for
characterizing different epigenetic states. We present a novel program, metilene, to identify …
characterizing different epigenetic states. We present a novel program, metilene, to identify …
[HTML][HTML] DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing
The ability to estimate the age of the donor from recovered biological material at a crime
scene can be of substantial value in forensic investigations. Aging can be complex and is …
scene can be of substantial value in forensic investigations. Aging can be complex and is …
TwinsUK: the UK adult twin registry update
S Verdi, G Abbasian, RCE Bowyer… - Twin Research and …, 2019 - cambridge.org
TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry
comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is …
comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is …
Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation
Background: Epigenome-wide association scans (EWAS) are under way for many complex
human traits, but EWAS power has not been fully assessed. We investigate power of EWAS …
human traits, but EWAS power has not been fully assessed. We investigate power of EWAS …
[HTML][HTML] Epigenetics of discordant monozygotic twins: implications for disease
Monozygotic (MZ) twins share nearly all of their genetic variants and many similar
environments before and after birth. However, they can also show phenotypic discordance …
environments before and after birth. However, they can also show phenotypic discordance …
TRPA1: a molecular view
JE Meents, CI Ciotu… - Journal of …, 2019 - journals.physiology.org
The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing
neurons and other tissues and has become a major target in the development of novel …
neurons and other tissues and has become a major target in the development of novel …
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
F Viana - The Journal of physiology, 2016 - Wiley Online Library
TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain
receptors, with a major role in chemonociception. TRPA1 has also been implicated in …
receptors, with a major role in chemonociception. TRPA1 has also been implicated in …