Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors

T Tomimatsu, K Mimura, S Matsuzaki, M Endo… - International journal of …, 2019 - mdpi.com
Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and
proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal …

Pre-eclampsia part 1: current understanding of its pathophysiology

T Chaiworapongsa, P Chaemsaithong, L Yeo… - Nature Reviews …, 2014 - nature.com
Pre-eclampsia is characterized by new-onset hypertension and proteinuria at≥ 20 weeks of
gestation. In the absence of proteinuria, hypertension together with evidence of systemic …

Endothelial dysfunction and preeclampsia: role of oxidative stress

LC Sánchez-Aranguren, CE Prada… - Frontiers in …, 2014 - frontiersin.org
Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria
at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is …

Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease

CE Powe, RJ Levine, SA Karumanchi - Circulation, 2011 - Am Heart Assoc
Preeclampsia is a clinical syndrome defined as the new onset of hypertension and
proteinuria during the second half of pregnancy. 1 It afflicts 3% to 5% of pregnancies and is …

Pathogenesis of preeclampsia

BC Young, RJ Levine… - Annual Review of …, 2010 - annualreviews.org
Preeclampsia is a systemic syndrome that occurs in 3 to 5% of pregnant women and
classically manifests as new-onset hypertension and proteinuria after 20 weeks of gestation …

Preeclampsia: the role of angiogenic factors in its pathogenesis

A Wang, S Rana, SA Karumanchi - Physiology, 2009 - journals.physiology.org
Preeclampsia, a systemic syndrome of pregnancy clinically characterized by new onset of
proteinuria and hypertension, is associated with significant morbidity and mortality to both …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

From pregnancy to preeclampsia: a key role for estrogens

N Berkane, P Liere, JP Oudinet, A Hertig… - Endocrine …, 2017 - academic.oup.com
Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …