Stress signaling pathways for the pathogenicity of Cryptococcus
YS Bahn, KW Jung - Eukaryotic cell, 2013 - Am Soc Microbiol
Sensing, responding, and adapting to the surrounding environment are crucial for all living
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …
Endoplasmic reticulum stress and fungal pathogenesis
K Krishnan, DS Askew - Fungal biology reviews, 2014 - Elsevier
The gateway to the secretory pathway is the endoplasmic reticulum (ER), an organelle that
is responsible for the accurate folding, post-translational modification and final assembly of …
is responsible for the accurate folding, post-translational modification and final assembly of …
Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …
Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans
J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …
mammalian host and cause disease. Although many of the factors responsible for …
Characterization of the Chromosome 4 Genes That Affect Fluconazole-Induced Disomy Formation in Cryptococcus neoformans
P Ngamskulrungroj, Y Chang, B Hansen, C Bugge… - PloS one, 2012 - journals.plos.org
Heteroresistance in Cryptococcus neoformans is an intrinsic adaptive resistance to azoles
and the heteroresistant phenotype is associated with disomic chromosomes. Two …
and the heteroresistant phenotype is associated with disomic chromosomes. Two …
The fungal UPR: A regulatory hub for virulence traits in the mold pathogen Aspergillus fumigatus
K Krishnan, DS Askew - Virulence, 2014 - Taylor & Francis
Aspergillus fumigatus is an opportunistic pathogen that is responsible for a life-threatening
fungal infection known as invasive aspergillosis. Current therapies for the treatment of this …
fungal infection known as invasive aspergillosis. Current therapies for the treatment of this …
Dnj1 Promotes Virulence in Cryptococcus neoformans by Maintaining Robust Endoplasmic Reticulum Homeostasis Under Temperature Stress
The capacity of opportunistic fungal pathogens such as Cryptococcus neoformans to cause
disease is dependent on their ability to overcome an onslaught of stresses including …
disease is dependent on their ability to overcome an onslaught of stresses including …
Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans
ALM Bloom, JTG Solomons, VE Havel… - Molecular …, 2013 - Wiley Online Library
The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and …
cause disease in its human host. In this study, we report that C. neoformans rapidly and …
The unfolded protein response (UPR) pathway in Cryptococcus
SA Cheon, KW Jung, YS Bahn, HA Kang - Virulence, 2014 - Taylor & Francis
Unique and evolutionarily conserved signaling pathways allow an organism to sense,
respond to, and adapt to internal and external environmental cues at its biological niche. In …
respond to, and adapt to internal and external environmental cues at its biological niche. In …
The cellular roles of CCR4-NOT in model and pathogenic fungi–implications for fungal virulence
The fungal Ccr4-NOT complex has been implicated in orchestrating gene expression
networks that impact on pathways key for virulence in pathogenic species. The activity of …
networks that impact on pathways key for virulence in pathogenic species. The activity of …