[PDF][PDF] Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
BR Stockwell - Cell, 2022 - cell.com
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …
Targeting ferroptosis as a vulnerability in cancer
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …
body of evidence suggests that iron imbalance is the common denominator in many …
[PDF][PDF] The hallmarks of cancer metabolism: Still emerging
Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …
[PDF][PDF] Ferroptosis at the intersection of lipid metabolism and cellular signaling
D Liang, AM Minikes, X Jiang - Molecular cell, 2022 - cell.com
Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …
to play an important role in multiple diseases including cancer, neurodegeneration, and …
Cancer metabolism: looking forward
I Martínez-Reyes, NS Chandel - Nature Reviews Cancer, 2021 - nature.com
Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …
Cancer cells autonomously alter their flux through various metabolic pathways in order to …
The role of lipids in cancer progression and metastasis
M Martin-Perez, U Urdiroz-Urricelqui, C Bigas… - Cell metabolism, 2022 - cell.com
Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …
as a signaling molecule, and being a structural component of membranes); however, an …
Identification of essential sites of lipid peroxidation in ferroptosis
AN von Krusenstiern, RN Robson, N Qian… - Nature chemical …, 2023 - nature.com
Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, provides a
potential treatment avenue for drug-resistant cancers and may play a role in the pathology of …
potential treatment avenue for drug-resistant cancers and may play a role in the pathology of …
Broadening horizons: the role of ferroptosis in cancer
The discovery of regulated cell death processes has enabled advances in cancer treatment.
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …
Ferroptosis: mechanisms, biology and role in disease
X Jiang, BR Stockwell, M Conrad - Nature reviews Molecular cell …, 2021 - nature.com
The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …