Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to
coordinate cell growth, metabolism and autophagy. Extensive research has mapped the …

The vertebrate thymus provides an inductive environment for T-cell development. Within the
mouse thymus, Notch signals are indispensable for imposing the T-cell fate on multipotential …

Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century,
with purported benefit in gout, hangover, insomnia, and early suggestions that lithium …

Canonical Wnt signaling has been implicated in the regulation of hematopoiesis. By
employing a Wnt-reporter mouse, we observed that Wnt signaling is differentially activated …

Abstract Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a
complex array of critical cellular processes. It was initially identified in rat skeletal muscle as …

The mammalian target of rapamycin (mTOR), the key component of the protein complexes
mTORC1 and mTORC2, plays a critical role in cellular development, tissue regeneration …

Hematopoietic stem cell (HSC) self renewal and lineage commitment depend on complex
interactions with the microenvironment. The ability to maintain or expand HSCs for clinical …

Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of
rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in …