Neurodegenerative diseases: Regenerative mechanisms and novel therapeutic approaches
Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …
Microtubules: From understanding their dynamics to using them as potential therapeutic targets
Y Ilan - Journal of cellular physiology, 2019 - Wiley Online Library
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …
Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex
The development of neural circuits relies on axon projections establishing diverse, yet well-
defined, connections between areas of the nervous system. Each projection is formed by …
defined, connections between areas of the nervous system. Each projection is formed by …
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome
The investigation of genetic forms of juvenile neurodegeneration could shed light on the
causative mechanisms of neuronal loss. Schinzel-Giedion syndrome (SGS) is a fatal …
causative mechanisms of neuronal loss. Schinzel-Giedion syndrome (SGS) is a fatal …
Convergent and divergent mechanisms of epileptogenesis in mTORopathies
Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to
mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a …
mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a …
A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy
C Liu, Y Zhang, X She, L Fan, P Li, J Feng, H Fu… - Journal of hematology & …, 2018 - Springer
Background Despite the overwhelming number of investigations on AKT, little is known
about lncRNA on AKT regulation, especially in GBM cells. Methods RNA-binding protein …
about lncRNA on AKT regulation, especially in GBM cells. Methods RNA-binding protein …
NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice
Autism spectrum disorders are neurodevelopmental conditions with diverse aetiologies, all
characterized by common core symptoms such as impaired social skills and communication …
characterized by common core symptoms such as impaired social skills and communication …
Audiogenic seizures in the Fmr1 knock-out mouse are induced by Fmr1 deletion in subcortical, VGlut2-expressing excitatory neurons and require deletion in the …
D Gonzalez, M Tomasek, S Hays, V Sridhar… - Journal of …, 2019 - Soc Neuroscience
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the
leading monogenetic cause of autism. One symptom of FXS and autism is sensory …
leading monogenetic cause of autism. One symptom of FXS and autism is sensory …
Timing as a mechanism of development and evolution in the cerebral cortex
LR Fenlon - Brain, behavior and evolution, 2022 - karger.com
One of the biggest mysteries in neurobiology concerns the mechanisms responsible for the
diversification of the brain over different time scales, ie during development and evolution …
diversification of the brain over different time scales, ie during development and evolution …
Lysine deacetylation by HDAC6 regulates the kinase activity of AKT in human neural progenitor cells
The AKT family of serine–threonine kinases functions downstream of phosphatidylinositol 3-
kinase (PI3K) to transmit signals by direct phosphorylation of a number of targets, including …
kinase (PI3K) to transmit signals by direct phosphorylation of a number of targets, including …