Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Optic vesicle formation, transformation into an optic cup and integration with neighboring
tissues are essential for normal eye formation, and involve the coordinated occurrence of …

Th17 cells have been described as short lived, but this view is at odds with their capacity to
trigger protracted damage to normal and transformed tissues. We report that Th17 cells …

Wnt/β-catenin signaling is highly active in the dorsal retinal pigment epithelium (RPE) during
eye development. To study the role of Wnt/β-catenin signaling in the RPE development we …

The embryonic chick occupies a privileged place among animal models used in
developmental studies. Its rapid development and accessibility for visualization and …

Cleft lip, which results from impaired facial process growth and fusion, is one of the most
common craniofacial birth defects. Many genes are known to be involved in the etiology of …

A crucial step in eye organogenesis is the transition of the optic vesicle into the optic cup.
Several transcription factors and extracellular signals mediate this transition, but whether a …

Septo-optic dysplasia (SOD) is a congenital brain anomaly that results in pituitary, optic
nerve, and midline forebrain defects. The etiology of SOD is poorly understood, with the …

Transcription factors (TFs) and long noncoding RNAs (lncRNAs) contribute to gastric cancer
(GC). However, the roles of TFs and lncRNAs in the invasion and metastasis of GC remain …

The homeodomain is found in hundreds of transcription factors that play roles in fate
determination via cell-autonomous regulation of gene expression. However, some …