The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

Mounting evidence indicates that the nervous system plays a central role in cancer
pathogenesis. In turn, cancers and cancer therapies can alter nervous system form and …

The recently uncovered key role of the peripheral and central nervous systems in controlling
tumorigenesis and metastasis has opened a new area of research to identify innovative …

The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively
in the lateral hypothalamus. They act on two specific receptors that are widely distributed …

Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …

Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region
known to orchestrate diverse functions including sleep, reward processing, food intake …

The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …

Cancer is not just a lump of cells that divide, invade, and spread randomly, but rather a multi-
layered precisely tuned process that requires the participation of the whole organism. There …

Sleep is essential for health. Indeed, poor sleep is consistently linked to the development of
systemic disease, including depression, metabolic syndrome, and cognitive impairments …

Background It is increasingly recognized that cancer progression induces systemic immune
changes in the host. Alterations in number and function of immune cells have been identified …