Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice

E Mittal, GVRK Prasad, S Upadhyay, J Sadadiwala… - Nature …, 2024 - nature.com
Mycobacterium tuberculosis (Mtb) infects several lung macrophage populations, which have
distinct abilities to restrict Mtb. What enables Mtb survival in certain macrophage populations …

Mycobacterium smegmatis MraZ Regulates Multiple Genes within and Outside of the dcw Operon during Hypoxia

IM Suleiman, H Yu, J Xu, J Zhen, H Xu… - ACS Infectious …, 2024 - ACS Publications
Mycobacterium tuberculosis is the most ancient human tuberculosis pathogen and has been
the leading cause of death from bacterial infectious diseases throughout human history …

CD4+ T cells recruit, then engage macrophages in cognate interactions to clear Mycobacterium tuberculosis from the lungs.

SH Becker, CE Ronayne, TD Bold, MK Jenkins - bioRxiv, 2024 - biorxiv.org
IFN-γ-producing CD4+ T cells are required for protection against lethal Mycobacterium
tuberculosis (Mtb) infections. However, the ability of CD4+ T cells to suppress Mtb growth …