Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

In response to infection or cell damage, inflammasomes form intracellular multimeric protein
complexes that play an essential role in host defense. Activation results in the maturation …

The recognition of cellular damage caused by either pathogens or abiotic stress is essential
for host defense in all forms of life in the plant and animal kingdoms. The NOD-like receptors …

Traditional views of the inflammasome highlight the assembly of pre-existing core
components shortly after infection or tissue damage. Emerging work, however, suggests that …

Nod-like receptor (NLR) proteins activate pyroptotic cell death and IL-1 driven inflammation
by assembling and activating the inflammasome complex. Closely related sensor proteins …

Although chaperone‐assisted protein crystallization remains a comparatively rare
undertaking, the number of crystal structures of polypeptides fused to maltose‐binding …

Guanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely
distributed among eukaryotes. They are interferon (IFN)-inducible guanosine …

Crystallization chaperones have been used to facilitate the crystallization of challenging
proteins. Even though the maltose-binding protein (MBP) is one of the most commonly used …

Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses
to danger stimuli and infection, and their dysregulation is associated with an increasing …

Inflammasomes are multiprotein complexes, which are assembled in response to a diverse
range of exogenous pathogens and endogenous danger signals, leading to produce pro …