Redox signaling at the crossroads of human health and disease

J Zuo, Z Zhang, M Luo, L Zhou, EC Nice, W Zhang… - MedComm, 2022 - Wiley Online Library
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Elucidating the metabolic plasticity of cancer: mitochondrial reprogramming and hybrid metabolic states

D Jia, JH Park, KH Jung, H Levine, BA Kaipparettu - Cells, 2018 - mdpi.com
Aerobic glycolysis, also referred to as the Warburg effect, has been regarded as the
dominant metabolic phenotype in cancer cells for a long time. More recently, it has been …

The Membrane-Bound NAC Transcription Factor ANAC013 Functions in Mitochondrial Retrograde Regulation of the Oxidative Stress Response in Arabidopsis

I De Clercq, V Vermeirssen, O Van Aken… - The Plant …, 2013 - academic.oup.com
Upon disturbance of their function by stress, mitochondria can signal to the nucleus to steer
the expression of responsive genes. This mitochondria-to-nucleus communication is often …

Nuclear-mitochondrial interactions

BR Walker, CT Moraes - Biomolecules, 2022 - mdpi.com
Mitochondria, the cell's major energy producers, also act as signaling hubs, interacting with
other organelles both directly and indirectly. Despite having its own circular genome, the …

[HTML][HTML] Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

VN Kotiadis, MR Duchen, LD Osellame - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background The maintenance of cell metabolism and homeostasis is a fundamental
characteristic of living organisms. In eukaryotes, mitochondria are the cornerstone of these …

The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high‐fat diet‐fed obese …

H Yuan, Y Li, F Ling, Y Guan, D Zhang, Q Zhu, J Liu… - Aging cell, 2020 - Wiley Online Library
We have recently reported that epigallocatechin gallate (EGCG) could extend lifespan in
healthy rats. This study aimed to investigate the effects and mechanisms of a high dose of …

Molecular mechanisms of Saccharomyces cerevisiae stress adaptation and programmed cell death in response to acetic acid

S Giannattasio, N Guaragnella, M Ždralević… - Frontiers in …, 2013 - frontiersin.org
Beyond its classical biotechnological applications such as food and beverage production or
as a cell factory, the yeast Saccharomyces cerevisiae is a valuable model organism to study …

The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy …

Y Niu, L Na, R Feng, L Gong, Y Zhao, Q Li, Y Li… - Aging cell, 2013 - Wiley Online Library
It is known that phytochemicals have many potential health benefits in humans. The aim of
this study was to investigate the effects of long‐term consumption of the phytochemical …

[HTML][HTML] The retrograde response: when mitochondrial quality control is not enough

SM Jazwinski - Biochimica et biophysica acta (BBA)-Molecular cell …, 2013 - Elsevier
Mitochondria are responsible for generating adenosine triphosphate (ATP) and metabolic
intermediates for biosynthesis. These dual functions require the activity of the electron …

Mitochondrial retrograde signaling: triggers, pathways, and outcomes

FM Da Cunha, NQ Torelli… - Oxidative medicine and …, 2015 - Wiley Online Library
Mitochondria are essential organelles for eukaryotic homeostasis. Although these
organelles possess their own DNA, the vast majority (> 99%) of mitochondrial proteins are …