Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

Background Biofilms are multicellular communities of microorganisms held together by a self-
produced extracellular matrix. The ability of microbes to form biofilm is a universal …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Mitochondria is one of the main source of oxidative stress (ROS), as it utilizes the oxygen for
the energy production. ROS and RNS are normally generated by tightly regulated enzymes …

Ischemic stroke is the major type of cerebrovascular disease usually resulting in death or
disability among the aging population globally. Oxidative stress has been closely linked with …

Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been
widely utilized for chemical mechanical planarization in the semiconductor industry and for …

Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

Liver fibrosis represents a health problem with significant morbidity and mortality that affects
100 million people worldwide. It is a final pathway to several chronic liver diseases and is …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS, eg nitric oxide, NO) are
well recognised for playing a dual role as both deleterious and beneficial species. ROS and …

Stroke is one of the leading causes of mortality and morbidity, with astronomical financial
repercussions on health systems worldwide. Ischaemic stroke accounts for approximately 80 …